Principles of Pharmacology



Principles of Pharmacology


Learning Objectives



1. Define, spell, and pronounce the terms listed in the vocabulary.


2. Apply critical thinking skills in performing patient assessment and care.


3. Distinguish among the government agencies that regulate drugs in the United States.


4. Cite the areas covered in the regulations established by the Drug Enforcement Administration (DEA) for the management of controlled or regulated substances.


5. List the DEA regulations for prescription drugs for each of the five schedules of the Controlled Substance Act.


6. Explain the medical assistant’s role in preventing drug abuse.


7. Differentiate among a drug’s chemical, generic, and trade names.


8. Describe the use of drug reference materials.


9. Explain the five pregnancy risk categories for drugs.


10. Define the five medical terms used to describe the clinical use of drugs.


11. Cite safety measures for the use of over-the-counter (OTC) drugs.


12. Diagram the parts of a prescription.


13. Demonstrate the ability to transcribe a prescription accurately.


14. Relate the principles of pharmacokinetics to drug use.


15. Describe factors that affect the action of a drug.


16. Compare the therapeutic classifications of medications.


17. Differentiate among commonly used herbal remedies and alternative therapies.


18. Examine the role of the medical assistant in drug therapy education.


19. Identify the medical assistant’s legal responsibilities in medication management in an ambulatory care setting.


Vocabulary


angina pectoris (an-ji′-nuh/pek′-tuh-ruhs) Spasmlike pain in the chest caused by myocardial anoxia.


bronchodilator (brahn-ko-di′-la-tuhr) Drug that relaxes contractions of the smooth muscle of the bronchioles to improve lung ventilation.


cirrhosis (suh-ro′-suhs) Chronic, degenerative disease of the liver that interferes with normal liver function.


colloidal (kah-loid′-uhl) Pertaining to a gluelike substance.


enteric-coated Term that refers to an oral medication that is coated to protect the drug against the stomach juices; this design is used to ensure that the medicine is absorbed in the small intestine.


formulary List of drugs compiled by a health insurance company that identifies the drugs the insurance company will cover under benefits.


generic Medication that is not protected by trademark.


hypercholesterolemia (hi-per-kuh-les-tuh-ruh-le′-me-uh) Elevated blood levels of cholesterol.


lumen An open space, such as within a blood vessel or the intestine, or in the inside of a needle or an examining instrument.


metabolic alkalosis Condition characterized by significant loss of acid in the body or an increased amount of bicarbonate; severe metabolic alkalosis can lead to coma and death.


over-the-counter (OTC) drugs Medications sold without a prescription.


spermicide (spuhr′-muh-side) Chemical substance that kills sperms cells.


therapeutic range The blood concentration of a drug that produces the desired effect without toxicity.


tinnitus A noise sensation of ringing heard in one or both ears.


Scenario


Kathy Augustino, CMA (AAMA), was hired recently to work for a primary care physician in her hometown. Her responsibilities include administering medications to a wide range of patients. To give patients medications correctly and safely in the ambulatory setting, she must understand the basic principles of pharmacology.


While studying this chapter, think about the following questions:



Pharmacology is the broad science of the origin, nature, chemistry, effects, and uses of drugs. Clinical pharmacology is the study of the biologic effects of a drug used as a medical treatment and the actions of a drug in the body over time, including the rate at which it is absorbed by body tissues; where it is distributed or localized in the tissues; the route by which it is excreted; and its toxicity, or poisonous effect.


Medical assistants must have a general understanding of the types of drugs available and their uses. For every medication administered, a medical assistant must understand the drug’s action, typical side effects, route of administration, and recommended dose, as well as the individual patient factors that can alter the drug’s effect and elimination. Drugs are constantly being developed and released for patient treatment; therefore, medical assistants must continually update their knowledge of specific drugs used in the ambulatory care setting. Correct management of drug administration and patient education are crucial factors in providing safe drug therapy for all patients.


Government Regulation


Several federal agencies combine forces to regulate, safeguard, and manage the development and use of medications in the United States. The Food and Drug Administration (FDA), a division of the Department of Health and Human Services, regulates the development and sale of all prescription and over-the-counter (OTC) drugs. Pharmaceutical companies developing new medications must gain FDA approval before the drugs can be sold to consumers. The approval process begins with chemical testing in the laboratory and progresses to toxicity testing in laboratory animals, and finally to human clinical trials, which involve volunteers who participate in controlled drug studies. Only one of 10 new drugs ever reaches the clinical testing phase. If the drug is found to have an acceptable benefit-to-risk ratio (i.e., it is effective without causing an unacceptable degree of harm to the user), the FDA approves the medication for release.


The original manufacturer of the drug is awarded copyright protection on that particular chemical compound for 17 years; this means that during the 17-year period, other pharmaceutical companies cannot produce generic copies of the drug. Besides approving new drugs for the marketplace, the FDA establishes manufacturing standards for drug purity and strength and ensures that generic brands are effective and safe.





Controlled Substances


The Drug Enforcement Administration (DEA) was established in 1973 as part of the Department of Justice to enforce federal laws regarding the use of illegal drugs. According to the Controlled Substances Act (CSA), which was passed in 1970, a drug or other substance that has the potential for illegal use and abuse must be placed on the controlled substance list. Any new medication with an action similar to a drug already on the controlled substance list also is considered to have the potential for abuse.


Most controlled drugs provide significant assistance to patients in need of their particular actions, such as pain relief or anesthesia for surgery. However, certain guidelines must be followed to comply with the storage of controlled substances, their record keeping, and security requirements. In addition, federal law requires that all medical personnel, including medical assistants, share the responsibility for managing controlled substances on site. Precautions must be taken to monitor patients’ drug use, protect prescription pads, maintain the records required by law, and report any known or suspected drug diversion or theft.


According to the guidelines set forth in the CSA, controlled substances are divided into five sections, or schedules, depending on their addictive abilities and likely degree of abuse. The classifications range from Schedule I drugs, which are illegal and cannot be prescribed, to Schedule V medications, which have the least potential for addiction and abuse (Table 33-1).



TABLE 33-1


Classification of Controlled Substances





























SCHEDULE GUIDELINES DRUG EXAMPLES
I
Heroin, lysergic acid diethylamide (LSD), marijuana, methaqualone (Quaalude), mescaline (peyote), amphetamine variations, phencyclidine (PCP), Ecstasy, GHB acetylcodone, Dipipan
II
Opium extracts, morphine, methadone, cocaine precursors, amphetamine, barbiturates, methylphenidate (Ritalin), oxycodone (Percocet or OxyContin), hydromorphone HCl (Dilaudid), meperidine HCl (Demerol), codeine, alfentanil (Alfenta), alphaprodine (Nisentil), Burgodin, secobarbital (Seconal), fentanyl
III
Paregoric, acetaminophen and codeine (Tylenol with codeine), benzphetamine, suppositories with barbiturates, anabolic steroids, testosterone, butabarbital (Butisol), Fiorinal, Voranil, Empirin, hydrocodone (Vicodin), buprenorphine
IV
Meprobamate (Equanil), chlordiazepoxide (Librium), diazepam (Valium), flurazepam (Dalmane), chloral hydrate, propoxyphene napsylate (Darvon), Rohypnol (“date rape” drug), pentazocine lactate (Talwin), alprazolam (Xanax), triazolam (Halcion), temazepam (Restoril), chlorazepate dipotassium (Tranxene), lorazepam, Klonopin, (Ativan), zolpidem tartrate (Ambien), barbital, Lexatin, Urbanyl, clonazepam (Klonopin), diethylpropion (Tenuate), Motofen, Capla, midazolam (Versed), Donnatal, Meridia, zolpidem tartrate (Ambien), eszopiclone (Lunesta)
V
Cough medicines containing limited quantity of codeine (Robitussin A-C), alkaloids, kaolin and pectin belladonna (Donnagel), diphenoxylate with atropine (Lomotil)
May be sold by a pharmacist in some states; buyer must be 18 years old and must show identification


Image


Every medical practice that stores and administers medications that fall into any of the schedule categories should have a copy of the controlled substances regulations. This list can be obtained from the regional DEA office. It is also important to ensure that the office is included on the DEA’s mailing list, so that the practice receives updates as drugs are added, deleted, or moved from one schedule to another.


Regulation of Controlled Substances


Specific CSA regulations govern the record keeping, physician registration, and inventory of controlled substances. Complete, accurate records on the purchase and management of scheduled drugs in the ambulatory care setting must be maintained. These records must be kept separate from the patient’s medical record for 2 years and must be readily available for inspection by the DEA at all times. Each time a controlled substance is dispensed and administered in the office, documentation of that process includes the number of doses of the drug on site both before and after the medication is dispensed. Medical practices that dispense and administer controlled substances on site use forms developed for this purpose. Any discrepancy in the count of the medication available must be documented and co-signed by two employees.


Every physician who prescribes or has controlled substances on site must register with the DEA for a Controlled Substance Registration Certificate. The physician receives a specific DEA registration number that must be included on all controlled substance prescriptions. The certificate is renewable every 3 years and is specific to a particular site of practice. Therefore, if the physician dispenses or prescribes scheduled drugs at more than one site, a DEA registration number must be obtained for each site.


All controlled substances must be stored in a safe or immovable locked cabinet, and the keys must be kept in a secure location. Prescription forms should be kept out of areas used by patients and preferably secured in an area that prohibits unauthorized or illegal use. All DEA forms used by the facility to order controlled substances also must be kept in a locked area.


Many ambulatory practices no longer keep controlled substances on site. However, if drugs are lost or stolen, the incident must be reported immediately to the regional DEA office and to local law enforcement authorities. If a controlled substance is damaged or must be discarded (e.g., a pill falls to the floor during dispensing), two employees must be present to witness the medication being flushed down the sink or toilet, and both must document the procedure on the controlled substance inventory form used by that office. If a large quantity of scheduled drugs must be discarded, the local DEA office should be contacted for guidance.



33-1


Critical Thinking Application


Kathy is responsible for maintaining the inventory of controlled substances in the office. While checking the supply of meperidine, she notices that the expiration date on the medication is today. She must dispose of the remaining two pills. According to DEA regulations, how should she dispose of the medication?


Individual states also may regulate controlled substances; therefore, it is essential that medical assistants know their state’s legal requirements.


Specific guidelines apply to prescription orders for controlled substances:



Other specific rules may apply, depending on the schedule to which the prescribed controlled substance is assigned. The symbols C-II, C-III, C-IV, and C-V are used to indicate the specific schedule:



• Schedule II (C-II) prescriptions:


• Must be written unless an absolute emergency exists that requires a telephone prescription order. The amount in the phone order is limited to that needed during the emergency, and the physician must deliver a written prescription to the pharmacy within 72 hours.


• Cannot be refilled


• In certain states, must be provided as multiple-copy prescription order forms


• Schedule III (C-III) and IV (C-IV) prescriptions:


• May be ordered orally or in writing


• May be refilled up to five times within 6 months of the original order


• Schedule V (C-V) prescriptions:


• May be ordered orally or in writing


• May be refilled up to five times within 6 months of the original order


• Depending on the state, may be dispensed by the pharmacist without a prescription



33-2


Critical Thinking Application


Kathy is responsible for the orientation of a new medical assistant in the practice. Summarize the important points about government regulation of controlled substance prescriptions that she should include in the orientation.


Drug Abuse


Any drug, from aspirin to alcohol, can be misused or abused. The use of illegal and legal drugs has increased tremendously. Treatment programs for drug abuse are available throughout the United States for people from all walks of life. Programs include detoxification, rehabilitation, and long-term rehabilitation maintenance.


Medical assistants may encounter patients who are misusing or abusing drugs. It is important to be alert to the symptoms of drug dependence and to notify the physician when you suspect that a patient, or a co-worker, may have a problem with drug or alcohol dependency.


Drug misuse is the improper use of common drugs that can lead to dependence or toxicity. Examples of people with chronic dependencies include those who cannot have a bowel movement unless they take a laxative; those who have used nasal decongestants for so long that they cannot breathe without the use of nasal sprays; and those who take so many antacids that they suffer systemic metabolic alkalosis.


Drug abuse is the continuous or periodic self-administration of a drug that could result in addiction (physical dependence). Drug dependency is the inability to function unless under the influence of a substance; it may be psychological or physical. Psychological dependency is the compulsive craving for the effects of a substance. Habituation is a mild form of psychological dependency, such as the need for caffeine. Physical dependency, or addiction, is a person’s need to use a substance continuously so that the body can function, and also to prevent physical discomfort. This type of dependency occurs when abused substances produce biochemical changes in cells and tissues, most commonly in the nervous system. When a substance that causes physical dependency is discontinued, withdrawal symptoms occur. Withdrawal symptoms may be mild or serious, leading to convulsions and possibly death.


Regardless of the type of drug abused, it will have two effects on the person: acute and chronic. The acute effect is what the person feels when intoxicated, or directly under the influence of a particular substance. Chronic effects include the temporary or permanent physical and mental changes that result from long-term abuse.


Medical assistants often must answer patients’ questions about drug abuse. The medical assistant should read and keep up to date on drug-related issues. Pamphlets and agency referral names should be available for patients. In addition, patients’ concerns and questions about drug abuse should be conveyed to the physician.



Drug Names


A single drug may have up to three names: a chemical name, a generic name, and a trade name. The chemical name represents the drug’s exact formula. For example, the chemical name of the analgesic acetaminophen is N-(4-hydroxyphenyl). Acetaminophen is the generic name, and the trade name is Tylenol. All drugs are assigned a generic, or nonproprietary (official), name. This name is much simpler than the chemical name, and it is not protected by copyright. The trade, or brand, name is assigned by the manufacturer and is protected by copyright. To prevent confusion, the use of generic names rather than trade names is encouraged. Drugs also are classified by their use. For example, Advil is a brand name for the generic drug ibuprofen, which is classified as an analgesic and an anti-inflammatory agent.


Approaches to Studying Pharmacology


A pharmaceutical glossary could be a book in itself. Many terms are combinations of the condition to be treated plus the prefix anti- (e.g., antianginal, antianxiety, antiarrhythmic, anticoagulant, anticonvulsant, antidiarrheal). Notice how these names emphasize the drug’s effect (use) rather than its action in the body. More recent classifications, such as parasympathomimetic and cholinesterase inhibitor, describe the pharmacologic action rather than the therapeutic use. Both viewpoints are necessary for a more complete understanding of drugs and their action in the human body. No one can remember all there is to know about clinical pharmacology. The number of new drugs introduced into use far exceeds the number of older drugs replaced or discontinued. The number of drugs available for clinical use grows beyond the ability to learn all there is to know about each medication. Therefore, it is essential that a medical assistant understand how to use pharmacology resource books as references.


Drug Reference Materials


Reference books that are updated annually or periodically should be available for easy reference at all medical facilities. Most references list drug information in the following sequence:



1. Action: How the drug provides therapeutic results in the body, or the use of the drug.


2. Indication: The conditions for which the drug is used.


3. Contraindications: Conditions that make administration of the drug improper or undesirable.


4. Precautions: Necessary actions that must be taken because of special conditions of the patient, the drug, or the environment; they need to be considered if the drug is to be successful or not harmful. The drug’s pregnancy risk category is included in this section, as are precautions for nursing mothers (Table 33-2).


5. Adverse reactions: Commonly observed side effects on a tissue or organ system other than the one targeted by the medication. Adverse reactions include hypersensitivity, which causes an allergic reaction to the drug; idiosyncrasy, or an unexplained, unusual response to the drug; psychological dependence or habituation to the drug; and physical dependence on the compound, causing signs and symptoms of withdrawal in the patient if the medication is removed. For example, patients prescribed certain diuretics (e.g., Lasix) are at risk for potassium depletion, so they must take a potassium supplement or must eat a daily dietary source of potassium (bananas are a common source) to prevent complications.


6. Dosage and administration: Usual route, dosage, and timing for administering the drug.


7. How supplied: Description of how the medication is packaged and specifics on how it should be administered.



TABLE 33-2


Pregnancy Risk Drug Categories






















DRUG CATEGORY RISK/DESCRIPTION
A Remote risk.
Controlled studies in women have failed to demonstrate risk to fetus.
B Slightly more risk than A.
Animal studies show no risk, but controlled human studies have not been done; or animal studies show risk, but controlled studies in women have shown no risk.
C Greater risk than B.
Animal studies have shown risk, but no controlled human studies have been done; or no studies have been done in animals or women.
D Proven risk of fetal harm.
Human studies show proof of fetal damage, but the potential benefits of use during pregnancy may make its use acceptable.
X Proven risk of fetal harm.
Studies in women or animals show definite risk of fetal abnormality. Risks outweigh any possible benefit.

Package Inserts


Every drug package contains an insert describing all the significant aspects of using the drug, including information on the chemical formulation of the drug and clinical studies. The information in the insert is controlled by the FDA and serves as an excellent quick reference on new medications in the ambulatory setting.


Physicians’ Desk Reference


The Physicians’ Desk Reference (PDR) is published annually by Thomson Medical Economics Company (Oradell, New Jersey). The PDR is provided free to physicians who subscribe to Medical Economics magazine. Copies can be purchased through the publisher or in local bookstores. Supplements are published quarterly throughout the year. The PDR contains information on approximately 2,500 drugs and includes product descriptions that are identical to the information provided in package inserts. The drug manufacturers pay for this space, so the PDR could be considered the Yellow Pages of the drug industry. The PDR is the most commonly used drug reference book and should be available in all healthcare facilities.


The book’s sections are color-coded and cross-referenced for easy use. The various sections allow you to begin searching for information about a drug from any starting point. You can start with the usage, classification, generic name, manufacturer’s name, or trade name of a drug or what the drug looks like. A special photographic section enables visual identification of products. Once you know which drug you want to study, the product information section lists the actual package insert information alphabetically, first by the manufacturer, then by the brand name. A separate PDR volume, the Physicians’ Desk Reference for Nonprescription Drugs, is published annually for OTC drugs and dietary supplements. The six sections of the PDR are color-coded as follows:



U.S. Pharmacopeia/National Formulary


The U.S. Pharmacopeia/National Formulary (USP/NF) is the official source of drug standards for the United States. The Pharmacopeia was combined with the National Formulary, which lists the chemical formulas for all accepted drugs. This combined reference lists and describes all approved medications in the United States considered useful and therapeutic in the practice of medicine. Single drugs rather than combined products (compound mixtures) are listed. If a drug name is the same as the official name in this volume, the drug is followed by the initials USP (e.g., digitoxin, USP).


Learning About Drugs


The study of pharmacology is difficult at best. However, a few tips can help make it easier:



• First, take advantage of opportunities to observe the use of drugs in patient care. Studying about atorvastatin calcium (Lipitor) becomes more meaningful when you see how its lipid-lowering action actually affects a patient’s blood cholesterol level.


• Second, concentrate on the most important drugs in each classification. As you expand your knowledge to other drugs in each category, you will easily understand new drugs by noting the similarities and differences between them and the basic, important drugs you studied first.


• Third, learn about a drug’s primary action and use, then expand your knowledge to its other actions and uses. Soon you will be able to name the drug that is usually indicated for a particular condition. By knowing a drug’s secondary effects, you will be able to understand what side effects are likely to occur during use of the drug. More important, you will be aware of contraindications to use of the drug. Knowledge of the drug’s actions will enable you to predict what toxic reactions might occur from an overdose.



Dispensing Drugs


Drugs are dispensed in two ways: over the counter and by prescription. OTC drugs are available to the public for self-medication without a prescription. These drugs have been approved by the FDA for general consumer use, but patients taking prescription drugs should keep their healthcare providers informed about their OTC drug use.


A medical assistant directly involved in patient care should have an understanding of some basic facts about OTC drugs. Today patients are better informed about their personal healthcare, and many want to be active participants in healthcare decisions. They need facts to make informed choices when using OTC preparations. Most OTC preparations are safe if used as directed on the package; however, patient education contributes greatly to the safe and correct use of OTCs. Patients should be encouraged to do the following when choosing or using an OTC:



The number of prescription drugs that have been granted OTC status is constantly increasing, and as the list of OTC drugs increases, so does the need for consumer education. Many OTC medications influence the safety and effectiveness of prescription drugs; therefore, gathering information to discern a complete and accurate pattern of the patient’s use of OTC drugs should be part of every visit to the physician.


Prescription Drugs


Federal law makes drugs that are dangerous, powerful, or habit-forming illegal to use except under a physician’s order. A prescription is an order written by the physician for the dispensing of a particular medication by the pharmacist and its administration to the patient. Sometimes an order may be written by the physician on the patient’s medical record; however, most often it is an order written on a prescription blank for the pharmacist to fill (Figure 33-1). The prescription must be signed by the physician, or the order cannot be carried out (Procedure 33-1). If the physician requests that the medical assistant phone in a prescription to the pharmacy, all pertinent information for the medication order must be written down and reviewed by the physician for accuracy before the call is made. A note is made in the patient’s chart that a medication order was phoned into the pharmacy, with all of the pertinent information about the order included.




Procedure 33-1


Maintain Medication and Immunization Records


Prepare a Prescription for the Physician’s Signature


GOAL:To accurately prepare a prescription for the physicians signature using the appropriate abbreviations and prescription format.


EQUIPMENT and SUPPLIES



Procedural Steps



1. Refer to the physician’s written order for the prescription. If the physician gives a verbal order to write a prescription, write down the order and review it with the physician for accuracy.
PURPOSE: To ensure accuracy in writing the ordered medication.


2. If you are unfamiliar with the medication, look it up in a drug reference book (e.g., the PhysiciansDesk Reference [PDR]).
PURPOSE: The medical assistant should be familiar with the details of the drug, including the correct spelling, form in which it is dispensed, strength, recommended dose, storage guidelines, drug-drug interactions, and possible side effects, to make sure the transcription is correct and to be prepared to answer the patient’s questions about the medication.


3. Ask the patient about drug allergies.
PURPOSE: The patient should be asked about drug allergies each time a medication is prescribed or dispensed, because these can change over time.


4. Using a prescription pad that has the physician’s name, address, telephone number, and DEA registration number preprinted on the slip, begin to transcribe the physician’s order (refer to Figure 33-1).


5. Record the patient’s name and address and the date on which the prescription is being written.


6. Next to the Rx, write in legible handwriting the name of the drug (correctly spelled), the dosage form (e.g., tablet, capsule, or other, using correct abbreviations), and the strength ordered. This is the inscription. For example, if the physician orders Lipitor, 40-mg tablets, by mouth, one tablet at bedtime, the first line of the prescription should read: Lipitor 40 mg tabs.


7. On the next line, write Disp. This is the subscription, which includes directions to the pharmacist on the amount to be dispensed and the form of the drug. For the Lipitor order, the subscription would read: Disp: #30.


8. Next comes the signature. This includes directions for the patient, such as how and when to take the medicine; it usually is preceded by the abbreviation Sig: For the Lipitor order, the signature would read: Sig: image tab po hs.


9. The physician has told you that the patient can get three refills of the prescription, so this information should be added at the bottom of the prescription on the designated line.


10. The physician must review and sign the prescription before it is given to the patient.


11. Document in the patient’s medical record the medication order and any pertinent details, including patient education and refill information.
PURPOSE: All patient education should be documented for future reference, and the details about the prescription, as well as refill information, must be included for future prescriptions and/or refill orders.


Telephoning a Prescription Into the Pharmacy


Using the steps outlined above, complete the prescription including the patient’s full name and address; the practitioner’s full name and address; the DEA number if the prescription is for a controlled substance (Schedule II drugs must be filled with a written prescription and/or an EHR program that is authorized to fill scheduled drugs); and the drug name, strength, dosage form, quantity prescribed, direction for use, and the number of refills (it any) authorized. The physician must review the prescription for accuracy before the medical assistant telephones the pharmacy. Document the telephoned pharmacy order in the patient’s medical record as you would for any prescribed drug.


Appropriate medical terminology and abbreviations must be used to complete the prescription. The more common terms and abbreviations are listed in Table 33-3. In an attempt to reduce the number of medication errors caused by incorrect use of medical terminology, the Joint Commission (formerly known as The Joint Commission on Accreditation of Healthcare Organizations [JCAHO]) recently developed a “Do Not Use” list of abbreviations, acronyms, and symbols that should not be used for documentation purposes in accredited institutions. The Joint Commission also created an ancillary list of possible future inclusions. Both of these lists are presented in Table 33-4. In addition to the Joint Commission lists, facilities have the option of creating their own list of problematic abbreviations that employees should avoid using.



TABLE 33-3


Common Prescription Abbreviations




































































































































































































































































































ABBREVIATION MEANING ABBREVIATION MEANING ABBREVIATION MEANING
aa of each ID intradermal pt patient
ac before meals IM intramuscular pt pint
ad lib as desired IV intravenous pulv powder
agit shake, stir K potassium qh every hour
am morning kg kilogram q2h every 2 hours
amp ampule KVO keep vein open q3h every 3 hours
AD right ear L liter q4h every 4 hours
AS left ear lb pound qid four times a day
ASA aspirin LR lactated Ringer’s solution qm every morning
AU both ears image minim qn every night
aq water mcg microgram qod every other day
bid twice a day med medicine qs quantity sufficient
C cup, Celsius meq milliequivalent qt quart
image with mg milligram R rectal
cap capsule mL milliliter Rx take, treatment
CC chief complaint MLD minimum lethal dose r/o rule out
cc cubic centimeter mn midnight S, Sig give the following directions
cm centimeter MO mineral oil image or w/o without
c/o complaining of MOM milk of magnesia SC, SQ, subQ subcutaneous
D/C discharge MS morphine sulfate SOB shortness of breath
Dx diagnosis MTD maximum tolerated dose image one-half
dil dilute NKA no known allergies stat immediately
disp dispense noct at night sub-q subcutaneous
dr dram NPO nothing by mouth T, tbs tablespoon
EENT eye, ear, nose, throat NS normal saline t, tsp teaspoon
ext extract N/V nausea/vomiting TAB tablet
F Fahrenheit O2 oxygen tid three times a day
FDA Food and Drug Administration OD overdose tinct tincture
FE iron OD right eye TO telephone order
fl fluid OS left eye tus cough
fx fracture OU both eyes ung ointment
gal gallon OTC over-the-counter (drugs) vag vagina
gm, g gram oz ounce ves bladder
gr grain pc after meals VO verbal order
gtt drops PL placebo VS vital signs
h hour pm afternoon W/O water in oil
hs at bedtime PMI patient medication instruction WNL within normal limits
HTN hypertension po by mouth x times
Hx history pr per rectum y/o years old
inj injection prn as needed    

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Apr 6, 2017 | Posted by in MEDICAL ASSISSTANT | Comments Off on Principles of Pharmacology

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