Macrolide Antibiotics
Macrolide Antibiotics PREGNANCY CATEGORY B OR C Therapeutic Actions Macrolides are antibiotics. They are bacteriostatic or bactericidal in susceptible bacteria; they bind to cell membranes and cause changes in protein…
HMG-CoA Inhibitors
HMG-CoA Inhibitors PREGNANCY CATEGORY X Therapeutic Actions HMG-CoA inhibitors are antihyperlipidemic. They are a fungal metabolite that inhibits the enzyme that catalyzes the first step in the cholesterol synthesis pathway…
Histamine2 (H2) Antagonists
Histamine2 (H2) Antagonists PREGNANCY CATEGORY B Therapeutic Actions H2 antagonists inhibit the action of histamine at the H2 receptors of the stomach, inhibiting gastric acid secretion and reducing total pepsin…
Fluoroquinolones
Fluoroquinolones PREGNANCY CATEGORY C Therapeutic Actions Fluoroquinolones are antibacterial. They interfere with DNA replication in susceptible gram-negative bacteria, preventing cell reproduction and leading to death of bacteria. Indications Treatment of…
Corticosteroids
Corticosteroids PREGNANCY CATEGORY C Therapeutic Actions Corticosteroids enter target cells and bind to cytoplasmic receptors, initiating many complex reactions that are responsible for anti-inflammatory, immunosuppressive (glucocorticoid), and salt-retaining (mineralocorticoid) actions….
Cephalosporins
Cephalosporins PREGNANCY CATEGORY B Therapeutic Actions Cephalosporins are antibiotics. They are bactericidal, inhibiting synthesis of bacterial cell wall, causing cell death in susceptible bacteria. Indications Treatment of pharyngitis, tonsillitis caused…
Calcium Channel Blockers
Calcium Channel Blockers PREGNANCY CATEGORY C Therapeutic Actions Calcium channel blockers are antianginal and antihypertensive. They inhibit the movement of calcium ions across the membranes of cardiac and arterial muscle…
Bisphosphonates
Bisphosphonates PREGNANCY CATEGORY D (PARENTERAL) PREGNANCY CATEGORY C (ORAL) Therapeutic Actions Bisphosphonates inhibit bone resorption, possibly by inhibiting osteoclast activity and promoting osteoclast cell apoptosis; this action leads to decreased…
Beta-adrenergic Blockers (β-blockers)
Beta-adrenergic Blockers (β-blockers) PREGNANCY CATEGORY C (MOST) PREGNANCY CATEGORY D (ATENOLOL) PREGNANCY CATEGORY B (ACEBUTOLOL, PINDOLOL, SOTALOL) Therapeutic Actions Beta-adrenergic blockers are antianginals, antiarrhythmics, and antihypertensives. These drugs competitively block…
