Drugs Used to Treat Constipation and Diarrhea
Objectives
1 Explain the meaning of “normal” bowel habits and describe the underlying causes of constipation.
3 Cite nine causes of diarrhea.
4 Differentiate between locally acting and systemically acting antidiarrheal agents.
6 Cite conditions that generally respond favorably to antidiarrheal agents.
Key Terms
constipation () (p. 551)
laxatives () (p. 551)
diarrhea () (p. 551)
Constipation
http://evolve.elsevier.com/Clayton
Constipation is defined as “a symptom-based disorder of unsatisfactory defecation and is characterized by infrequent stools, difficult stool passage, or both. Difficult stool passage includes straining, a sense of difficulty passing stool, incomplete evacuation, hard/lumpy stools, prolonged time to stool, or need for manual maneuvers to pass stool. Chronic constipation is defined as the presence of these symptoms for at least 3 months” (American College of Gastroenterology Chronic Constipation Task Force, 2005). Chronic constipation afflicts about 15% of North Americans and is more predominant in women, affecting two to three females for every male affected.
Constipation may result from decreased motility of the colon or from retention of feces in the lower colon or rectum. In either case, the longer the feces remain in the colon, the greater the reabsorption of water and the drier the stool becomes. The stool is then more difficult to expel from the anus. Causes of constipation include the following: improper diet, too little residue or too little fluid (e.g., lacking fruits and vegetables or high in constipating foods such as cheese and yogurt); too little fluid intake, especially considering the climate; lack of exercise and sedentary habits (e.g., “couch potato” with remote control); failure to respond to the normal defecation impulses; muscular weakness of the colon; diseases such as anemia and hypothyroidism; frequent use of constipating medications (e.g., morphine, codeine, anticholinergic agents); tumors of the bowel or pressure on the bowel from tumors; and diseases of the rectum.
Occasional constipation is not detrimental to a person’s health, although it can cause a feeling of general discomfort or abdominal fullness, anorexia, and anxiety in some people. Habitual constipation leads to decreased intestinal muscle tone, increased straining at the stool as the person bears down in the attempt to pass the hardened stool, and an increased incidence of hemorrhoids. Using laxatives (medications that stimulate the bowels to evacuate stool) or enemas daily should be avoided because they decrease the muscular tone and mucus production of the rectum and may result in water and electrolyte imbalance. They also become habit-forming; the weakened muscle tone adds to the inability to expel the fecal contents, which leads to the continued use of enemas or laxatives.
Today, many believe that even occasional failure of the bowel to move daily is abnormal and should be treated. Daily bowel movements are frequently not necessary. Many people have “normal” bowel habits even though they have only two or three bowel movements per week. As long as the patient’s health is good and the stool is not hardened or impacted, this schedule is acceptable.
Diarrhea
Diarrhea is an increase in the frequency or fluid content of bowel movements. Because normal patterns of defecation and the patient’s perception of bowel function vary, a careful history must be obtained to determine the change in a particular patient’s bowel elimination pattern. An important fact to remember about diarrhea is that diarrhea is a symptom rather than a disease.
Causes of Diarrhea
Intestinal Infections
Intestinal infections are most frequently associated with ingestion of food contaminated with bacteria or protozoa (food poisoning) or eating or drinking water that contains bacteria foreign to the patient’s gastrointestinal (GI) tract. People traveling, especially to other countries, develop what is known as traveler’s diarrhea from ingestion of microorganisms that are pathogenic to their GI tracts but not to those of the local residents.
Spicy or Fatty Foods
Spicy or fatty foods may produce diarrhea by irritating the lining of the GI tract. Diarrhea occurs particularly when the patient does not routinely eat these types of foods. This type of diarrhea may occur while an individual is traveling or on vacation (e.g., eating fresh oysters daily while visiting coastal regions).
Enzyme Deficiencies
Patients with deficiencies of digestive enzymes, such as lactase or amylase, have difficulty digesting certain foods. Diarrhea usually develops because of irritation from undigested food.
Excessive Use of Laxatives
People who use laxatives on a routine chronic basis but are not under the care of a health care provider for a specific GI problem are laxative abusers. Some do it for weight control, and others use laxatives under the misconception that a person is not normal if the bowels do not move daily.
Drug Therapy
Diarrhea is a common adverse effect caused by irritation of the GI lining by ingested medication. Diarrhea may also result from the use of antibiotics that may kill certain bacteria that live in the GI tract and help digest food.
Emotional Stress
Diarrhea is a common symptom of emotional stress and anxiety.
Hyperthyroidism
Hyperthyroidism induces increased GI motility, resulting in diarrhea.
Inflammatory Bowel Disease
Inflammatory bowel diseases such as diverticulitis, ulcerative colitis, gastroenteritis, and Crohn’s disease cause inflammation of the GI lining, resulting in muscle spasm and diarrhea.
Surgical Bypass
Surgical bypass procedures of the intestine often result in chronic diarrhea because of the decreased absorptive area remaining after surgery. Incompletely digested food and water rapidly pass through the GI tract.
Treatment of Altered Elimination
Constipation
Constipation that does not have a specific cause can often be treated without the use of laxatives. A high-fiber diet (e.g., fruits, grains, nuts, vegetables), adequate hydration (e.g., eight to ten 8-ounce glasses of water daily), and daily exercise (e.g., for physical activity, stress relief) can eliminate most cases of constipation. Laxatives, other than treating acute constipation from a specific cause (e.g., a change in routine such as traveling for long hours in a car or plane), should be avoided. The ingredients of laxative products frequently cause adverse effects and may be contraindicated in certain patients. The following patients should not take laxatives and should be referred to a health care provider: those with severe abdominal discomfort or pain; those who have nausea, vomiting, or fever; those with a pre-existing condition (e.g., diabetes mellitus, abdominal surgery); those taking medicines that cause constipation (e.g., iron, aluminum antacids, antispasmodics, muscle relaxants, opiates); those who have used other laxatives without success; and laxative abusers.
Diarrhea
Diarrhea may be acute or chronic, mild or severe. Because it may be a defense mechanism to rid the body of infecting organisms or irritants, it is usually self-limiting. Chronic diarrhea may indicate a disease of the stomach or small or large intestine, may be psychogenic, or may be one of the first symptoms of cancer of the colon or rectum. If diarrhea is severe or prolonged, it may cause dehydration, electrolyte depletion, and physical exhaustion. Specific antidiarrheal therapy depends on the cause of the diarrhea.
Nursing Implications for Constipation and Diarrhea
Assessment
History
Medications.
Ask the patient to provide a list of all current medications prescribed by a health care provider as well as all over-the-counter (OTC) medications that are being taken. Are any used to treat diarrhea or constipation? Are any of these medications known to slow intestinal transit time (e.g., narcotic analgesics, aluminum-containing antacids, anticholinergic agents)? Are any known to cause diarrhea (e.g., magnesium-containing antacids)?
Activity and Exercise.
Ask the patient about daily activity level and exercise. Does the patient play vigorous sports, take walks or jog, or have a sedentary job and hobby?
Elimination Pattern.
What is the individual’s usual pattern of stool elimination (i.e., frequency of the urge to defecate, usual stool consistency, presence of bloating or flatus, fecal incontinence)? Does the individual have a history of, or currently have, anal fissures, hemorrhoids, or abscesses?
Nutritional History
Basic Assessment
Laboratory Studies
History.
Plan to perform a focused assessment consistent with the symptoms and the underlying pathology.
Medications, Treatments, and Diagnostics
Nutrition.
Obtain specific orders relating to nutrition. Diet orders depend on the cause of constipation or diarrhea. A dietary consult may be indicated. Schedule fluid intake of at least 3000 mL/day, unless contraindicated by coexisting conditions (e.g., heart failure, renal disease). Rehydration solutions may be required with severe diarrhea. Does the patient have any food intolerances or foods known to produce diarrhea or constipation?
Activity and Exercise.
Mark the Kardex or enter data in the computer with specific orders regarding ambulation. Whenever possible, encourage frequent ambulation.
Implementation
• Initiate nutritional interventions such as high-fiber foods and adequate fluid intake.
• Give prescribed laxatives or stool softeners. Monitor for effectiveness and adverse effects.