Selective Serotonin Reuptake Inhibitors (SSRIs) PREGNANCY CATEGORY C Therapeutic Actions The SSRIs act as antidepressants by inhibiting CNS neuronal uptake of serotonin with little or no effect on norepinephrine; they…
Phosphodiesterase Type 5 Inhibitors PREGNANCY CATEGORY B Therapeutic Actions Selectively inhibits cGMP-specific phosphodiesterase type 5. The mechanism of penile erection involves the release of nitric oxide into the corpus cavernosum…
Phenothiazines PREGNANCY CATEGORY C Therapeutic Actions Mechanism of action of phenothiazines is not fully understood. Antipsychotic drugs block postsynaptic dopamine receptors in the brain, but this may not be necessary…
Penicillins PREGNANCY CATEGORY B Therapeutic Actions Penicillins are antibiotics. They are bactericidal, inhibiting the synthesis of cell wall of sensitive organisms, causing cell death in susceptible organisms. Indications Treatment of…
Nonsteroidal Anti-inflammatory Drugs (NSAIDs) PREGNANCY CATEGORY B OR C Therapeutic Actions NSAIDs have anti-inflammatory, analgesic, and antipyretic activities largely related to inhibition of prostaglandin synthesis; exact mechanisms of action are…
Nondepolarizing Neuromuscular Junction Blockers (NMJ Blockers) DANGEROUS DRUG PREGNANCY CATEGORY C Therapeutic Actions NMJ blockers interfere with neuromuscular transmission and cause flaccid paralysis by blocking acetylcholine receptors at the skeletal…
Macrolide Antibiotics PREGNANCY CATEGORY B OR C Therapeutic Actions Macrolides are antibiotics. They are bacteriostatic or bactericidal in susceptible bacteria; they bind to cell membranes and cause changes in protein…
HMG-CoA Inhibitors PREGNANCY CATEGORY X Therapeutic Actions HMG-CoA inhibitors are antihyperlipidemic. They are a fungal metabolite that inhibits the enzyme that catalyzes the first step in the cholesterol synthesis pathway…
