Zolpidem Tartrate(zol’ pih dem)
Ambien, Ambien CRDNC, EdluarDNC, Intermezzo, Zolpimist
PREGNANCY CATEGORY C
CONTROLLED SUBSTANCE C-IV
Drug Class
Hypnotic (nonbarbiturate)
Therapeutic Actions
Modulates GABA receptors to cause suppression of neurons, leading to sedation, anticonvulsant, anxiolytic, and relaxant properties.
Indications
Short-term treatment of insomnia
Treatment of insomnia in adults who experience difficulties with sleep onset and sleep maintenance (ER tablets)
Treatment of insomnia when middle-of-the-night awakening is followed by difficulty returning to sleep when patient has at least 4 hr of bedtime remaining (Intermezzo)
Contraindications and Cautions
Contraindicated with hypersensitivity to zolpidem.
Use cautiously with acute intermittent porphyria, impaired hepatic or renal function, addiction-prone patients, history of depression, pregnancy, lactation.
Available Forms
Tablets—5, 10 mg; ER tabletsDNC—6.25, 12.5 mg; oral spray—5 mg; sublingual tablet—1.75, 3.5, 5, 10 mg
Dosages
Adults
10 mg PO at bedtime. Do not exceed 10 mg/day. ER tablets—12.5 mg/day PO. Oral spray—Two to three sprays in mouth, over tongue at bedtime. Or, 1.75 mg (women) or 3.5 mg (men) sublingually with middle-of-the-night awakening (Intermezzo); limit to 1.75 mg once per night if also on CNS depressants.
Pediatric patients
Safety and efficacy not established.
Geriatric patients
Increased chance of confusion, acute brain syndrome; initiate treatment with 5 mg PO or 6.25 mg/day PO ER tablets, or 1.75 mg sublingually (Intermezzo).
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