Zolmitriptan(zohl mah trip’ tan)
ZomigDNC, Zomig-ZMT
PREGNANCY CATEGORY C
Drug Classes
Antimigraine drug
Serotonin selective agonist
Therapeutic Actions
Binds to serotonin receptors to cause vascular constrictive effects on cranial blood vessels, causing the relief of migraine in select patients.
Indications
Treatment of acute migraine attacks with or without aura
Unlabeled use: Treatment of migraines in adolescents
Contraindications and Cautions
Contraindicated with allergy to zolmitriptan, active CAD, Prinzmetal angina, uncontrolled hypertension, pregnancy.
Use cautiously with the elderly and with lactation.
Available Forms
TabletsDNC—2.5, 5 mg; nasal spray—5 mg; orally disintegrating tablet—2.5, 5 mg
Dosages
Adults
Oral
For tablets or orally disintegrating tablets, 2.5 mg PO at onset of headache or with beginning of aura; may repeat dose if headache persists after 2 hr; do not exceed 10 mg in 24 hr.
Nasal spray
1 spray in nostril at onset of headache or beginning of aura; may repeat in 2 hr if needed. Maximum dose, 10 mg/24 hr (2 sprays).
Pediatric patients
Safety and efficacy not established.
Patients with hepatic impairment
Use caution; keep doses at 2.5 mg or less. Significant increases in BP can occur.
