Ethambutol Hydrochloride(e tham’ byoo tole)
Etibi (CAN), Myambutol
PREGNANCY CATEGORY C
Drug Classes
Antituberculotic (second line)
Therapeutic Actions
Inhibits the synthesis of metabolites in growing mycobacterium cells, impairing cell metabolism, arresting cell multiplication, and causing cell death.
Indications
Treatment of pulmonary TB in conjunction with at least one other antituberculotic
Contraindications and Cautions
Contraindicated with allergy to ethambutol; optic neuritis.
Use cautiously with impaired renal function, lactation, pregnancy (use other antituberculotics), visual problems (cataracts, diabetic retinopathy).
Available Forms
Tablets—100, 400 mg
Dosages
Ethambutol is not administered alone; use in conjunction with other antituberculotics.
Adults
Initial treatment: 15 mg/kg/day PO as a single daily oral dose. Continue therapy until bacteriologic conversion has become permanent and maximal clinical improvement has occurred.
Retreatment: 25 mg/kg/day as a single daily oral dose. After 60 days, reduce dose to 15 mg/kg/day as a single daily dose.
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