Valsartan(val sar’ tan)
Diovan
PREGNANCY CATEGORY D
Drug Classes
Angiotensin II receptor blocker
Antihypertensive
Therapeutic Actions
Selectively blocks the binding of angiotensin II to specific tissue receptors found in the vascular smooth muscle and adrenal gland; this action blocks the vasoconstricting effect of the renin–angiotensin system as well as the release of aldosterone, leading to decreased BP; may prevent the vessel remodeling associated with the development of atherosclerosis.
Indications
Treatment of hypertension, alone or in combination with other antihypertensives
Treatment of HF (New York Heart Association class II–IV)
Reduction in CV mortality in stable patients with left ventricular failure or left ventricular dysfunction following MI
Contraindications and Cautions
Contraindicated with hypersensitivity to valsartan, pregnancy (use during second or third trimester can cause injury or even death to fetus), lactation.
Use cautiously with hepatic or renal impairment, hypovolemia, hyperkalemia, HF, post-MI.
Available Forms
Tablets—40, 80, 160, 320 mg
Dosages
Adults
Hypertension: 80 mg PO daily; range 80–320 mg/day.
HF: Starting dose is 40 mg PO bid, titration to 80 mg and 160 mg PO bid should be done to the highest dose, as tolerated by the patient. Maximum daily dose is 320 mg given in divided doses. May be given in combination with other antihypertensives. Consider dosage reduction if used with diuretics.
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