
(toll tear’ oh deen)
Detrol, Detrol LADNC
PREGNANCY CATEGORY C
Drug class
Antimuscarinic
Therapeutic Actions
Competitively blocks muscarinic receptor sites; bladder contraction is mediated by muscarinic receptors—blocking these receptors decreases bladder contraction.
Indications
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Treatment of overactive bladder in patients with symptoms of urinary frequency, urgency or incontinence
Contraindications and Cautions
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Contraindicated with urinary retention, uncontrolled narrow-angle glaucoma, gastric retention, allergy to the drug or any of its components.
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Use cautiously with renal or hepatic impairment, pregnancy, lactation.
Available Forms
Tablets—1, 2 mg; ER capsulesDNC—2, 4 mg
Dosages
Adults
2 mg PO bid, may be lowered to 1 mg PO bid based on individual response; ER capsules—4 mg PO taken once daily; may be lowered to 2 mg once daily based on response.
Pediatric patients
Safety and efficacy not established.
Patients with hepatic and renal impairment
Reduce dosage to 1 mg PO bid (2 mg daily ER capsules) and monitor patient.

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