Tolterodine Tartrate(toll tear’ oh deen)
Detrol, Detrol LADNC
PREGNANCY CATEGORY C
Drug class
Antimuscarinic
Therapeutic Actions
Competitively blocks muscarinic receptor sites; bladder contraction is mediated by muscarinic receptors—blocking these receptors decreases bladder contraction.
Indications
Treatment of overactive bladder in patients with symptoms of urinary frequency, urgency or incontinence
Contraindications and Cautions
Contraindicated with urinary retention, uncontrolled narrow-angle glaucoma, gastric retention, allergy to the drug or any of its components.
Use cautiously with renal or hepatic impairment, pregnancy, lactation.
Available Forms
Tablets—1, 2 mg; ER capsulesDNC—2, 4 mg
Dosages
Adults
2 mg PO bid, may be lowered to 1 mg PO bid based on individual response; ER capsules—4 mg PO taken once daily; may be lowered to 2 mg once daily based on response.
Pediatric patients
Safety and efficacy not established.
Patients with hepatic and renal impairment
Reduce dosage to 1 mg PO bid (2 mg daily ER capsules) and monitor patient.
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