Tetrahydrozoline Hydrochloride(tet rah hi draz’ oh leen)
Tyzine
OTC ophthalmic preparation: Altazine Irritation Relief, Altazine, Moisture Relief, Murine Plus, Opti-Clear, Optigene 3, Visine, Visine AC, Visine Advanced Relief, Visine Maximum Redness Relief, Visine Totally Multisymptom Relief
PREGNANCY CATEGORY C
Drug Classes
Alpha agonist
Nasal decongestant
Ophthalmic decongestant
Ophthalmic vasoconstrictor and mydriatic
Therapeutic Actions
Acts directly on alpha receptors to produce vasoconstriction of arterioles in nasal passages, which produces a decongestant response; no effect on beta receptors; dilates pupils; increases flow of aqueous humor, vasoconstricts in eyes.
Indications
Intranasal: Symptomatic relief of nasal and nasopharyngeal mucosal congestion due to the common cold, hay fever, or other respiratory allergies
Ophthalmic: Temporary relief of redness, burning, and irritation due to dryness of the eye or discomfort due to minor irritations or to exposure to wind or sun
Contraindications and Cautions
Contraindicated with allergy to tetrahydrozoline, angle-closure glaucoma, anesthesia with cyclopropane or halothane, women in labor whose BP exceeds 130/80 mm Hg, concurrent MAOI use.
Use cautiously with angina, arrhythmias, prostatic hypertrophy, unstable vasomotor syndrome, lactation, thyrotoxicosis, diabetes, hypertension, CV disorders
Available Forms
Nasal solution—0.05%, 0.1%; nasal spray—0.1%; ophthalmic solution—0.5%
Dosages
Adults
Nasal
2–4 drops of 0.1% solution in each nostril three to four times/day; or 3–4 sprays in each nostril every 4 hr as needed. Never use more frequently than every 3 hr.
Ophthalmic
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