Terazosin Hydrochloride(ter ay’ zoe sin)
Apo-Terazocin (CAN), Hytrin, Novo-Terazocin (CAN), PMS-Terazocin (CAN), ratio-Terazocin (CAN), Teva-Terazosin (CAN)
PREGNANCY CATEGORY C
Drug Classes
Alpha1-adrenergic blocker
Antihypertensive
BPH drug
Therapeutic Actions
Drug selectively blocks postsynaptic alpha1-adrenergic receptors, decreasing peripheral vascular resistance, and lowering supine and standing BP; unlike conventional alpha-adrenergic blocking agents (eg, phentolamine), it does not also block alpha2 presynaptic receptors, does not cause reflex tachycardia. Relaxes the smooth muscle by blocking alpha1-adrenergic receptors in the bladder neck and prostate, thereby improving the symptoms of BPH.
Indications
Treatment of symptomatic BPH
Treatment of hypertension alone or in combination with other drugs
Unlabeled uses: Symptomatic treatment of ureteral stones, pediatric hypertension
Contraindications and Cautions
Contraindicated with hypersensitivity to terazosin and during lactation.
Use cautiously in patients taking other antihypertensives, pregnancy.
Available Forms
Capsules—1, 2, 5, 10 mg
Dosages
Adults
Adjust dose and dosing interval (12 or 24 hr) individually.
Hypertension: Initial dose, 1 mg PO at bedtime. Do not exceed 1 mg; strictly adhere to this regimen to avoid severe hypotensive reactions. Slowly increase dose to achieve desired BP response. Usual range, 1–5 mg PO daily. Up to 20 mg/day has been beneficial. Monitor BP 2–3 hr after dosing to determine maximum effect. If response is diminished after 24 hr, consider increasing dosage or use a twice daily regimen. If drug is not taken for several days, restart with initial 1-mg dose.
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
