Terazosin Hydrochloride(ter ay’ zoe sin)
Apo-Terazocin (CAN), Hytrin, Novo-Terazocin (CAN), PMS-Terazocin (CAN), ratio-Terazocin (CAN), Teva-Terazosin (CAN)
PREGNANCY CATEGORY C
Drug Classes
Alpha1-adrenergic blocker
Antihypertensive
BPH drug
Therapeutic Actions
Drug selectively blocks postsynaptic alpha1-adrenergic receptors, decreasing peripheral vascular resistance, and lowering supine and standing BP; unlike conventional alpha-adrenergic blocking agents (eg, phentolamine), it does not also block alpha2 presynaptic receptors, does not cause reflex tachycardia. Relaxes the smooth muscle by blocking alpha1-adrenergic receptors in the bladder neck and prostate, thereby improving the symptoms of BPH.
Indications
-
Treatment of symptomatic BPH
-
Treatment of hypertension alone or in combination with other drugs
-
Unlabeled uses: Symptomatic treatment of ureteral stones, pediatric hypertension
Contraindications and Cautions
-
Contraindicated with hypersensitivity to terazosin and during lactation.
-
Use cautiously in patients taking other antihypertensives, pregnancy.
Available Forms
Capsules—1, 2, 5, 10 mg
Dosages
Adults
Adjust dose and dosing interval (12 or 24 hr) individually.
-
Hypertension: Initial dose, 1 mg PO at bedtime. Do not exceed 1 mg; strictly adhere to this regimen to avoid severe hypotensive reactions. Slowly increase dose to achieve desired BP response. Usual range, 1–5 mg PO daily. Up to 20 mg/day has been beneficial. Monitor BP 2–3 hr after dosing to determine maximum effect. If response is diminished after 24 hr, consider increasing dosage or use a twice daily regimen. If drug is not taken for several days, restart with initial 1-mg dose.
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
