Sodium Oxybate



Sodium Oxybate





(soe’ dee um)

Xyrem

PREGNANCY CATEGORY B

CONTROLLED SUBSTANCE C-III


Drug Classes

Anticataplectic

CNS depressant


Therapeutic Actions

CNS depressant, its mechanism of action in affecting cataplexy is not understood.


Indications



  • Treatment of excessive daytime sleepiness and cataplexy in patients with narcolepsy


  • Unlabeled uses: Fibromyalgia pain, fatigue



Available Forms

Solution—500 mg/mL


Dosages

Adults

4.5 g/day PO divided into two equal doses of 2.25 g. Administer drug at bedtime and again 2.5–4 hr later. Doses may be increased no more than every 1–2 wk to a maximum of 9 g/day in increments of 1.5 g/day (0.75 g dose). Usual range, 6–9 g night.

Pediatric patients younger than 16 yr

Safety and efficacy not established.

Patients with hepatic impairment

Reduce initial dose by half, and adjust dosage to effect while watching closely for adverse reactions.

Jul 21, 2016 | Posted by in NURSING | Comments Off on Sodium Oxybate

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