Roflumilast



Roflumilast





(roe flu’ ma last)

Daliresp

PREGNANCY CATEGORY C


Drug Class

Phosphodiesterase-4 (PDE4) inhibitor



Therapeutic Actions

Selectively inhibits PDE4 activity, leading to an accumulation of intracellular cyclic AMP in lung cells. How this helps the COPD patient is not clearly understood.


Indications



  • Reduction of exacerbation risk in patients with severe COPD associated with chronic bronchitis and a history of exacerbation



Available Forms

Tablets—500 mcg


Dosages

Adults

500 mcg/day PO with or without food.

Pediatric patients younger than 18 yr

Safety and efficacy not established.

Patients with hepatic impairment

Contraindicated for patients with moderate to severe liver impairment (Child-Pugh class B or C).

Jul 21, 2016 | Posted by in NURSING | Comments Off on Roflumilast

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