Protamine Sulfate



Protamine Sulfate





(proe’ ta meen)

PREGNANCY CATEGORY C


Drug Class

Heparin antagonist


Therapeutic Actions

Strongly basic proteins found in salmon sperm; protamines form stable salts with heparin, which results in the immediate loss of anticoagulant activity; administered when heparin has not been given; protamine has weak anticoagulant activity.


Indications



  • Treatment of heparin overdose



Available Forms

Injection—10 mg/mL


Dosages

Dosage is determined by the amount of heparin in the body and the time that has elapsed since the heparin was given; the longer the interval, the smaller the dose required.

Adults and pediatric patients

1 mg IV neutralizes not less than 100 heparin units.

Jul 21, 2016 | Posted by in NURSING | Comments Off on Protamine Sulfate

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