Propylthiouracil (PTU)



Propylthiouracil (PTU)





(proe pill thye oh yoor’ a sill)

Propyl-Thyracil (CAN)

PREGNANCY CATEGORY D


Drug Class

Antithyroid drug


Therapeutic Actions

Inhibits the synthesis of thyroid hormones; partially inhibits the peripheral conversion of T4 to T3, the more potent form of thyroid hormone.


Indications



  • Hyperthyroidism


  • Unlabeled use: Reduces mortality associated with alcoholic liver disease



Available Forms

Tablets—50 mg, 100 mg (CAN)


Dosages

Administered usually in three equal doses every 8 hr.


Dosages

Adults

Initially, 300 mg/day PO in divided doses every 8 hr, up to 400–900 mg/day in severe cases. For maintenance, 100–150 mg/day in divided doses every 8 hr.

Pediatric patients

Reserve use for children allergic to or intolerant of other therapies.

6 yr and older: 50 mg/day PO with careful titration if needed. Give in divided doses every 8 hr. Monitor TSH and T4 levels carefully.

Jul 21, 2016 | Posted by in NURSING | Comments Off on Propylthiouracil (PTU)

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