Propofol Disodium(pro’ poe fall)
Diprivan
PREGNANCY CATEGORY B
Drug Class
Sedative/hypnotic
Therapeutic Actions
Thought to increase sensitivity to GABA, leading to inhibition of nervous transmission and CNS depression.
Indications
Induction and maintenance of general anesthesia
Monitored anesthesia care
Combined sedation and regional anesthesia
Intensive care unit (ICU) sedation of intubated and mechanically ventilated adults
Contraindications and Cautions
Contraindicated with history of hypersensitivity to components of drug; allergies to eggs, soy beans, or soy; pregnancy, lactation.
Use cautiously in elderly patients and patients with severe systemic diseases; dehydration; decreased myocardial function or reduced vascular tone; seizure disorders.
Available Forms
Single-use vials—10 mg/mL
Dosages
Adults
Induction of general anesthesia: 2–2.5 mg/kg IV at 40 mg every 10 sec.
Induction of general anesthesia in neurosurgical patients: 1–2 mg/kg IV at 20 mg every 10 sec.
Induction of general anesthesia in cardiac surgery: 0.5–1.5 mg/kg IV at 20 mg every 10 sec.
Maintenance of general anesthesia: 100–200 mcg/kg/min IV or intermittent bolus of 25–50 mg based on patient response.
Monitored anesthesia care: 25–75 mcg/kg/min IV based on patient response.
ICU sedation of intubated patients: 5–50 mcg/kg/min IV as a continuous infusion.
Pediatric patients 3–16 yr
Induction of general anesthesia: 2.5–3.5/kg IV over 20–30 sec.
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