Penicillin G Potassium



Penicillin G Potassium





(pen i sill’ in)


Penicillin G Potassium (Aqueous)

Crystapen (CAN), Pfizerpen


Penicillin G Sodium

PREGNANCY CATEGORY B


Drug Classes

Antibiotic

Penicillin antibiotic


Therapeutic Actions

Bactericidal: Inhibits synthesis of cell wall of sensitive organisms, causing cell death.


Indications



  • Treatment of severe infections caused by sensitive organisms—streptococci, pneumococci, staphylococci, Neisseria gonorrhoeae, Treponema pallidum, meningococci, Actinomyces israelii, Clostridium perfringens and tetani, Leptotrichia buccalis (Vincent disease), Spirillum minus or Streptobacillus moniliformis, Listeria monocytogenes, Fusobacterium fusiformisans, Pasteurella multocida, Erysipelothrix insidiosa, Escherichia coli, Enterobacter aerogenes, Alcaligenes faecalis, Salmonella, Shigella, Proteus mirabilis, Corynebacterium diphtheriae, Bacillus anthracis


  • Treatment of syphilis, gonococcal infections


  • Unlabeled use: Treatment of Lyme disease



Available Forms

Injection—1, 2, 3 million units/50 mL; powder for injection—5, 20 million units/vial


Dosages

Adults



  • Meningococcal meningitis: 1–2 million units every 2 hr IM or by continuous IV infusion of 20–30 million units/day.


  • Actinomycosis: 1–6 million units/day IM in divided doses every 4–6 hr for 6 wk or IV for cervicofacial cases; 10–20 million units/day IV for thoracic and abdominal diseases.


  • Clostridial infections: 20 million units/day in divided doses every 4–6 hr IM or IV with antitoxin therapy.


  • Fusospirochetal infections (Vincent disease): 5–10 million units/day IM or IV in divided doses every 4–6 hr.


  • Rat-bite fever: 12–20 million units/day IM or IV in divided doses every 4–6 hr for 3–4 wk.


  • Listeria infections: 15–20 million units/day IM or IV in divided doses every 4–6 hr for 2 or 4 wk (meningitis or endocarditis, respectively).


  • Pasteurella infections: 4–6 million units/day IM or IV in divided doses every 4–6 hr for 2 wk.


  • Erysipeloid endocarditis: 12–20 million units/day IM or IV in divided doses every 4–6 hr for 4–6 wk.


  • Diphtheria (adjunctive therapy with antitoxin to prevent carrier state): 2–3 million units/day IM or IV in divided doses every 4–6 hr for 10–12 days.

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Jul 21, 2016 | Posted by in NURSING | Comments Off on Penicillin G Potassium

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