Oxymetholone(ox i meth’ oh lone)
Anadrol-50
PREGNANCY CATEGORY X
CONTROLLED SUBSTANCE C-III
Drug Classes
Anabolic steroid
Hormone
Therapeutic Actions
Testosterone analogue with androgenic and anabolic activity; promotes body tissue-building processes and reverses catabolic or tissue-depleting processes; increases Hgb and red cell mass.
Indications
Anemias caused by deficient red cell production
Acquired or congenital aplastic anemia
Myelofibrosis and hypoplastic anemias due to myelotoxic drugs
Unlabeled use: HIV-associated wasting
Contraindications and Cautions
Contraindicated with known sensitivity to oxymetholone or anabolic steroids, prostate or breast cancer, BPH, pituitary insufficiency, MI, nephrosis, liver disease, hypercalcemia, pregnancy, lactation.
Use cautiously with diabetes; seizure disorders; migraines; hepatic, cardiac, or renal disease; HF.
Available Forms
Tablets—50 mg
Dosages
Adults and pediatric patients
1–5 mg/kg/day PO. Usual effective dose is 1–2 mg/kg/day. Give for a minimum trial of 3–6 mo. Following remission, patients may be maintained without the drug or on a lower daily dose. Continuous therapy is usually needed in cases of congenital aplastic anemia.
Pediatric patients
Use with extreme caution due to risk of serious disruption of growth and development; weigh benefits and risks.
Pharmacokinetics
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