Orphenadrine Citrate(or fen’ a dreen)
Banflex, Flexon, Norflex
PREGNANCY CATEGORY C
Drug Class
Skeletal muscle relaxant (centrally acting)
Therapeutic Actions
Precise mechanisms not known; acts in the CNS; does not directly relax tense skeletal muscles; does not directly affect the motor endplate or motor nerves.
Indications
Relief of discomfort associated with acute, painful musculoskeletal conditions; as an adjunct to rest, physical therapy, and other measures
Unlabeled use: 100 mg at bedtime for the treatment of leg cramps
Contraindications and Cautions
Contraindicated with hypersensitivity to orphenadrine, glaucoma, pyloric or duodenal obstruction, stenosing peptic ulcers, achalasia, cardiospasm (megaesophagus), prostatic hypertrophy, bladder neck obstruction, myasthenia gravis, lactation.
Use cautiously with cardiac decompensation, coronary insufficiency, cardiac arrhythmias, hepatic or renal impairment, pregnancy, allergy to sulfites with some products.
Available Forms
SR tabletsDNC—100 mg; injection—30 mg/mL; tablets—100 mg
Dosages
Adults
60 mg IV or IM. May repeat every 12 hr. Inject IV over 5 min. Alternatively, give 100 mg PO every morning and evening.
Pediatric patients
Safety and efficacy not established; not recommended.
Geriatric patients
Use caution and regulate dosage carefully; patients older than 60 yr frequently develop increased sensitivity to adverse CNS effects of anticholinergic drugs.
Pharmacokinetics
|
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
