Omeprazole(oh me’ pray zol)
Losec (CAN)DNC, PrilosecDNC, Prilosec OTCDNC, Zegerid (with sodium bicarbonate)DNC
PREGNANCY CATEGORY C
Drug Classes
Antisecretory drug
Proton pump inhibitor
Therapeutic Actions
Gastric acid-pump inhibitor: Suppresses gastric acid secretion by specific inhibition of the hydrogen-potassium ATPase enzyme system at the secretory surface of the gastric parietal cells; blocks the final step of acid production.
Indications
Short-term treatment of active duodenal ulcer
Treatment of heartburn or symptoms of GERD
Short-term treatment of active benign gastric ulcer
GERD, severe erosive esophagitis, poorly responsive symptomatic GERD
Long-term therapy: Treatment of pathologic hypersecretory conditions (Zollinger-Ellison syndrome, multiple adenomas, systemic mastocytosis)
Eradication of Helicobacter pylori with amoxicillin or metronidazole and clarithromycin
Prilosec OTC: Treatment of frequent heartburn (2 or more days per week)
Zegerid oral suspension: Reduction of risk of upper GI bleeding in critically ill patients; includes sodium bicarbonate
Unlabeled use: Posterior laryngitis
Contraindications and Cautions
Contraindicated with hypersensitivity to omeprazole or its components.
Use cautiously because of possible increased risk of Clostridium difficile infection.
Use cautiously with pregnancy, lactation.
Available Forms
DR capsulesDNC—10, 20, 40 mg; DR tabletsDNC—20 mg (OTC); powder for oral suspension—20, 40 mg/packet (Zegerid); capsulesDNC—20, 40 mg (Zegerid)
Dosages
Adults
Active duodenal ulcer: 20 mg PO daily for 2–8 wk. Should not be used for maintenance therapy.
Active gastric ulcer: 40 mg PO daily for 4–8 wk.
Severe erosive esophagitis or poorly responsive GERD: 20 mg PO daily for 4–8 wk. Do not use as maintenance therapy. An additional 4–8 wk course can be considered if needed.
Pathologic hypersecretory conditions: Individualize dosage. Initial dose is 60 mg PO daily. Doses up to 120 mg tid have been used. Administer daily amounts greater than 80 mg in divided doses.
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