Norethindrone Acetate



Norethindrone Acetate





(nor eth in’ drone)

Aygestin

PREGNANCY CATEGORY X


Drug Classes

Hormone

Progestin


Therapeutic Actions

Progesterone derivative. Progesterone transforms proliferative endometrium into secretory endometrium; inhibits the secretion of pituitary gonadotropins, which prevents follicular maturation and ovulation; and inhibits spontaneous uterine contraction. Progestins have varying profiles of estrogenic, antiestrogenic, anabolic, and androgenic activity.


Indications



  • Treatment of amenorrhea, abnormal uterine bleeding due to hormonal imbalance


  • Treatment of endometriosis


  • Base: Component of some hormonal contraceptive preparations



Available Forms

Tablets—5 mg


Dosages

Administer orally only.

Adults



  • Amenorrhea; abnormal uterine bleeding: 2.5–10 mg PO for 5–10 days during second half of theoretical menstrual cycle.


  • Endometriosis: 5 mg/day PO for 2 wk. Increase in increments of 2.5 mg/day every 2 wk until 15 mg/day is reached. May be maintained for 6–9 mo or until breakthrough bleeding demands temporary termination.

Jul 21, 2016 | Posted by in NURSING | Comments Off on Norethindrone Acetate

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