Naproxen(na prox’ en)
Naproxen
Apo-Naproxen (CAN), Apo-Naproxen EC (CAN), Apo-Naproxen SR (CAN), EC-Naprosyn, Gen-Naproxen EC (CAN), NaprelanDNC, Naprosyn, Novo-Naprox (CAN), Novo-Naprox-EC (CAN)
Naproxen Sodium
Aleve, Anaprox, Anaprox DSDNC, Apo-Napro-Na (CAN), Apo-Napro-Na, DS (CAN)DNC, Mediproxen, Midol Extended Relief, Novo Naprox Sodium (CAN), Novo Naprox Sodium DS (CAN)DNC, Novo Naprox SR (CAN)
PREGNANCY CATEGORY C
Drug Classes
Analgesic (nonopioid)
NSAID
Therapeutic Actions
Analgesic, anti-inflammatory, and antipyretic activities largely related to inhibition of prostaglandin synthesis; exact mechanisms of action are not known.
Indications
Mild to moderate pain
Treatment of primary dysmenorrhea, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendinitis, bursitis, acute gout
OTC use: Temporary relief of minor aches and pains associated with the common cold, headache, toothache, muscular aches, backache, minor pain of arthritis, pain of menstrual cramps, reduction of fever
Treatment of juvenile arthritis (Naproxen)
Contraindications and Cautions
Contraindicated with allergy to naproxen, salicylates, other NSAIDs; pregnancy; lactation, perioperative coronary artery bypass graft.
Use cautiously with asthma, chronic urticaria, CV dysfunction, hypertension, GI bleeding, peptic ulcer, impaired hepatic or renal function.
Available Forms
Tablets—250, 375, 500 mg; 220, 275, 412.5, 500 mg (as naproxen sodium); DR tablets—375, 500 mg; CR tabletsDNC—375, 500 mg; suspension—125 mg/5 mL
Dosages
Do not exceed 1,500 mg/day (1,650 mg/day naproxen sodium).
Adults
DR (EC-Naprosyn)DNC
Rheumatoid arthritis or osteoarthritis, ankylosing spondylitis: 375–500 mg PO bid.
CR (Naprelan)DNC
750–1,000 mg PO daily as a single dose.
Naproxen sodium
275–550 mg bid PO. May increase to 1.65 g/day for a limited period.
Naproxen tablets
250–500 mg PO bid.
Naproxen suspension
250 mg (10 mL), 375 mg (15 mL), 500 mg (20 mL) PO bid.
CR (Naprelan)DNC
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