Montelukast Sodium(mon tell oo’ kast)
Apo-Montelukast (CAN), Sandoz-Montelukast (CAN), Teva-Montelukast (CAN), Singulair
PREGNANCY CATEGORY B
Drug Classes
Antiasthmatic
Leukotriene receptor antagonist
Therapeutic Actions
Selectively and competitively blocks the receptor that inhibits leukotriene formation, thus blocking many of the signs and symptoms of asthma—neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These actions contribute to inflammation, edema, mucus secretion, and bronchoconstriction associated with the signs and symptoms of asthma.
Indications
-
Prophylaxis and chronic treatment of asthma in adults and children 12 mo and older
-
Relief of symptoms of seasonal allergic rhinitis in adults and children 2 yr and older
-
Relief of symptoms of perennial allergic rhinitis in adults and children 6 mo and older
-
Prevention of exercise-induced bronchoconstriction in patients 6 yr and older
-
Unlabeled uses: Chronic urticaria, atopic dermatitis, NSAID-induced urticaria
Contraindications and Cautions
-
Contraindicated with hypersensitivity to montelukast or any of its components; acute asthma attacks; status asthmaticus.
-
Use cautiously with pregnancy and lactation.
Available Forms
Tablets—10 mg; chewable tablets—4, 5 mg; granules—4 mg/packet
Dosages
Adults and patients 15 yr and older
One 10-mg tablet PO daily, taken in the evening. For exercise-induced bronchoconstriction, dose taken 2 hr before exercise and not repeated for at least 24 hr.
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
