Contraindicated with known hypersensitivity to the drug; glaucoma; adhesions between iris and lens; stenosing peptic ulcer, pyloroduodenal obstruction, paralytic ileus, intestinal atony, severe ulcerative colitis, toxic megacolon, symptomatic prostatic hypertrophy, bladder neck obstruction; bronchial asthma, COPD; cardiac arrhythmias, myocardial ischemia; sensitivity to anticholinergic drugs, bromides, tartrazine (tartrazine sensitivity is more common with allergy to aspirin); impaired metabolic, liver, or renal function; myasthenia gravis.

Use cautiously with hypertension, hyperthyroidism, HF, pregnancy, lactation, and in elderly patients.