Methocarbamol(meth oh kar’ ba mole)
Robaxin, Robaxin-750
PREGNANCY CATEGORY C
Drug class
Skeletal muscle relaxant (centrally acting)
Therapeutic Actions
Precise mechanism of action not known but may be due to general CNS depression; does not directly relax tense skeletal muscles or directly affect the motor end plate or motor nerves.
Indications
Relief of discomfort associated with acute, painful musculoskeletal conditions, as an adjunct to rest, physical therapy, and other measures
Control of neuromuscular manifestations of tetanus
Contraindications and Cautions
Contraindicated with hypersensitivity to methocarbamol; known or suspected renal pathology (parenteral methocarbamol is contraindicated because of polyethylene glycol 300 in vehicle).
Use cautiously in patients with epilepsy, pregnancy, lactation.
Available Forms
Tablets—500, 750 mg; injection—100 mg/mL
Dosages
Adults
Oral
Initially, 1.5 g four times a day PO. For the first 48–72 hr, 6 g/day or up to 8 g/day is recommended. For maintenance, 1 g four times a day or 750 mg every 4 hr PO or 1.5 g tid for total dosage of 4–4.5 g/day.
Tetanus: Up to 24 g/day may be needed.
Parenteral
1 g IM or IV; 2–3 g may be needed in severe cases. Do not exceed 3 g for longer than 3 days except when treating tetanus.
Pediatric patients
Oral
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