Menotropins(men oh troe’ pins)
Menopur, Repronex
PREGNANCY CATEGORY X
Drug Classes
Fertility drug
Hormone
Therapeutic Actions
A purified preparation of human gonadotropins; in women, produces ovarian follicular growth; when followed by administration HCG, produces ovulation; used with HCG for at least 3 mo to induce spermatogenesis in men with primary or secondary pituitary hypofunction who have previously achieved adequate masculinization with HCG administration.
Indications
Given with HCG sequentially to induce ovulation and pregnancy in anovulatory infertile patients without primary ovarian failure; used with HCG to stimulate multiple follicles for in vitro fertilization programs
Unlabeled use: Treatment of male infertility caused by hypogonotropic hypogonadism
Contraindications and Cautions
Contraindicated with known sensitivity to menotropins; high gonadotropin levels, indicating primary ovarian failure; overt thyroid or adrenal dysfunction; abnormal bleeding of undetermined origin; ovarian cysts or enlargement not due to polycystic ovary syndrome; intracranial lesion, such as pituitary tumor; pregnancy (women); normal gonadotropin levels, indicating pituitary function; elevated gonadotropin levels, indicating primary testicular failure; infertility disorders other than hypogonadotropin hypogonadism (men).
Use cautiously with lactation.
Available Forms
Powder or pellet for injection—75 international units FSH/75 international units LH
Dosages
To achieve ovulation, HCG must be given following menotropins when clinical assessment indicates sufficient follicular maturation as indicated by urinary excretion of estrogens.
Menopur, Repronex
225 units IM; then 75–150 units/day by subcutaneous injection up to a maximum of 450 units/day for no longer than 12 days (Repronex) or 20 days (Menopur). Base actual dose on follicular development.
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