Meclizine Hydrochloride(mek’ li zeen)
Bonamine (CAN), Bonine, Bonine for Kids
Oral prescription tablets: Antivert, Dramamine, Less Drowsy Formula, Vertin-32
PREGNANCY CATEGORY B
Drug Classes
Anticholinergic
Antiemetic
Antihistamine
Anti–motion-sickness drug
Therapeutic Actions
Reduces sensitivity of the labyrinthine apparatus; probably acts at least partly by blocking cholinergic synapses in the vomiting center, which receives input from the CTZ and from peripheral nerve pathways; peripheral anticholinergic effects may contribute to efficacy.
Indications
Prevention and treatment of nausea, vomiting, motion sickness
Possibly effective for the management of vertigo associated with diseases affecting the vestibular system
Contraindications and Cautions
Contraindicated with allergy to meclizine or cyclizine; tartrazine sensitivity (more common in patients with aspirin hypersensitivity).
Use cautiously with lactation, narrow-angle glaucoma, stenosing peptic ulcer, symptomatic prostatic hypertrophy, bronchial asthma, COPD, bladder neck obstruction, pyloroduodenal obstruction, cardiac arrhythmias, postoperative state (hypotensive effects may be confusing and dangerous), pregnancy.
Available Forms
Tablets—12.5, 25, 32, 50 mg; chewable tablets—25 mg; capsules—25 mg
Dosages
Adults and children older than 12 yr
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