Intravenous Therapy



Intravenous Therapy





GENERAL CONSIDERATIONS


Goals

The goals of intravenous (IV) therapy are to:



  • Maintain or replace body stores of water, electrolytes, vitamins, proteins, fats, and calories in the patient who cannot maintain an adequate intake by mouth.


  • Restore acid-base balance.


  • Restore the volume of blood components.


  • Administer safe and effective infusions of medications by using the appropriate vascular access.


  • Monitor central venous pressure (CVP).


  • Provide nutrition while resting the GI tract.


Physiologic Assimilation of Infusion Solutions


Principles



  • Tissue cells (such as epithelial cells) are surrounded by a semipermeable membrane.


  • Osmotic pressure is the “pulling” pressure demonstrated when water moves through the semipermeable membrane of tissue cells from an area of weaker concentration to stronger concentration of solute (eg, sodium ions and blood glucose). The end result is dilution and equilibration between the intracellular and extracellular compartments.


  • Extracellular compartment fluids primarily include plasma and interstitial fluid.


Types of Fluids


Isotonic

A solution that exerts the same osmotic pressure as that found in plasma.



  • 0.9% sodium chloride solution (normal saline).


  • Lactated Ringer’s solution.


  • Blood components.



    • Albumin 5%.


    • Plasma.


  • Dextrose 5% in water (D5W).


Hypotonic

A solution that exerts less osmotic pressure than that of blood plasma. Administration of this fluid generally causes dilution of plasma solute concentration and forces water to move into cells to reestablish intracellular and extracellular equilibrium; cells will then expand or swell.



  • 0.45% sodium chloride solution (half normal saline)


  • 0.33% sodium chloride solution (one third normal saline)


Hypertonic

A solution that exerts a higher osmotic pressure than that of blood plasma. Administration of this fluid increases the solute concentration of plasma, drawing water out of the cells and into the extracellular compartment to restore osmotic equilibrium; cells will then shrink.



  • D5W in normal saline solution.


  • D5W in half normal saline solution (only slightly hypertonic because dextrose is rapidly metabolized and renders only temporary osmotic pressure).



  • Dextrose 10% in water.


  • Dextrose 20% in water.


  • 3% or 5% sodium chloride solution.


  • Hyperalimentation solutions.


  • D5W in lactated Ringer’s solution.


  • Albumin 25%.


Composition of Fluids




  • Saline solutions—water and electrolytes (Na+, Cl).


  • Dextrose solutions—water or saline and calories.


  • Lactated Ringer’s solution—water and electrolytes (Na+, K+, Cl, Ca++, lactate).


  • Balanced isotonic solution—varies; water, some calories, electrolytes (Na+, K+, Mg++, Cl, HCO3, gluconate).


  • Whole blood and blood components.


  • Plasma expanders—albumin, mannitol, dextran, plasma protein fraction 5%, hetastarch; exert increased oncotic pressure, pulling fluid from interstitium into the circulation and temporarily increasing blood volume.


  • Parenteral hyperalimentation—fluid, electrolytes, amino acids, and calories.


Uses and Precautions with Common Types of Infusions

See Table 6-2, page 84, for signs and symptoms of water excess or deficit, and Table 6-3, page 84, for signs and symptoms of isotonic fluid excess or deficit.



  • D5W



    • Used to replace water (hypotonic fluid) losses, supply some caloric intake, or administer as carrying solution for numerous medications.


    • Should be used cautiously in patients with water intoxication (hyponatremia, syndrome of inappropriate antidiuretic hormone release). Should not be used as concurrent solution infusion with blood or blood components.


  • Normal saline solution



    • Used to replace saline (isotonic fluid) losses, administer with blood components, or treat patients in hemodynamic shock.


    • Should be used cautiously in patients with isotonic volume excess (heart failure, renal failure).


  • Lactated Ringer’s solution



    • Used to replace isotonic fluid losses, replenish specific electrolyte losses, and moderate metabolic acidosis. Use cautiously in patients with liver failure.








Table 6-1 Composition of Selected IV Solutions





















































































































































SOLUTION


TONICITY


Na+ (mEq/L)


K+ (mEq/L)


Cl (mEq/L)


Ca++ (mEq/L)


pH


mOsm/L


CALORIES


5% DW


Isotonic






5.0


253


170


10% DW


Hypertonic






4.6


561


340


0.9% NS


Isotonic


154



154



5.7


308



0.45% NS


Hypotonic


77



7



5.3


154



5% D and 0.9% NS


Hypertonic


154



154



4.2


561


170


5% D and 0.45% NS*


Slightly hypertonic


77



77



4.2


407


170


5% D and 0.2% NS


Isotonic


34



34



4.2


290


170


Lactated Ringer’s solution


Isotonic


148


4


156


4.5


6.7


309


9


5% DW and lactated Ringer’s solution


Slightly hypertonic


130


4


109


3.0


5.1


527


170


Normosol-R


Isotonic


140


5


96



6.4


295



Sodium lactate


Slightly hypertonic


167





6.9


333


55


1/6 molar










6% Dextran 75 and 0.9% NS


Isotonic


154



154



4.3


309



DW, dextrose in water; NS, normal saline.


*5% dextrose metabolizes rapidly in the blood and, in reality, produces minimal osmotic effects.


Lactate converts to bicarbonate in the liver.










Table 6-2 Signs and Symptoms of Water Excess or Deficit























SITE


HYPONATREMIA (WATER DEFICIT)


HYPONATREMIA (WATER EXCESS)


Central nervous system


• Muscle twitching


• Hyperactive tendon reflexes


• Convulsions


• Increased intracranial pressure, coma


• Restlessness


• Weakness


• Delirium


• Coma


Cardiovascular


• Increased blood pressure and pulse (if severe)


• Tachycardia


• Hypotension (if severe)


Tissues


• Increased salivation, tears


• Watery diarrhea


• Fingerprinting of skin


• Decreased saliva and tears


• Dry, sticky mucous membranes


• Red, swollen tongue


• Flushed skin


Other


• None


• Fever



TYPES OF INTRAVENOUS ADMINISTRATION


IV “Push”

IV “push” (or IV bolus) refers to the administration of a medication from a syringe directly into an ongoing IV infusion. It may also be given directly into a vein by way of an intermittent access device (saline or heparin lock).



Precautions and Recommendations



  • Before medication administration:



    • Review order and patient allergies.


    • Dilute the drug as indicated by pharmacy references. Many medications are irritating to veins and require sufficient dilution.


    • Determine the correct (safest) rate of administration. Consult the pharmacy or pharmaceutical text. Most medications are given slowly (rarely over less than 1 minute); sometimes as long as 30 minutes is required. Too rapid administration may result in serious adverse effects.


    • If IV push is to be given with an ongoing IV infusion or to follow another IV push medication, check pharmacy for possible incompatibility. It is always wise to flush the IV tubing or cannula with saline before and after administration of a drug.


    • Assess the patient’s condition and ability to tolerate the drug.


    • Assess patency of the IV line by the presence of blood return.



      • Lower-running IV bottle.


      • Withdraw with syringe before injecting medication.


      • Pinch IV tubing gently.


    • Ascertain the dwell time of the catheter. For infusion of vesicants (some chemotherapy agents), a catheter placement of 24 hours or less is advisable.



  • Watch the patient’s reaction to the drug during and after administration.



    • Be alert for major adverse effects, such as anaphylaxis, respiratory distress, tachycardia, bradycardia, or seizures. Stop the medication. Notify the health care provider and institute emergency procedures as necessary.


    • Assess for minor adverse effects, such as nausea, flushing, skin rash, or confusion. Stop medication and consult the health care provider.


  • Administer vesicants only through the side port of a running IV infusion.


  • Be familiar with facility policies and guidelines regarding how, where, and by whom IV push medications can be given.








Table 6-3 Signs and Symptoms of Isotonic Fluid Excess or Deficit



























SITE


EXCESS


DEFICIT


Central nervous system


• Confusion (if severe)


• Fatigue, apathy


• Anorexia


• Stupor, coma


Cardiovascular


• Elevated venous pressure


• Distended neck veins


• Increased cardiac output


• Heart gallops


• Pulmonary edema


• Orthostatic hypotension


• Flat neck veins


• Fast, thready pulse


• Hypotension


• Cool, clammy skin


Gastrointestinal


• Anorexia, nausea and vomiting


• Edema of stomach, colon, and mesentery


• Anorexia


• Thirst


• Silent ileus


Tissues


• Pitting edema


• Moist pulmonary crackles


• Soft, smal l tongue with longitudina l wrinkling


• Sunken eyes


• Decreased skin turgor


Metabolism


• None


• Mild increase in temperature




Continuous or Intermittent Infusion Using Infusion Control Devices

Continuous or intermittent IV infusions may be given through traditionally hung bags of solution and tubing, with or without flow rate regulators. IV, intra-arterial, and intrathecal (spinal) infusion may be accomplished through the use of special external or implantable pumps. See Procedure Guidelines 6-1, pages 86 to 88.


General Considerations



  • Advantages



    • Ability to infuse large and small volumes of fluid with accuracy.


    • An alarm warns of problems, such as air in line, high pressure required to infuse, or, ultimately, occlusion.


    • Reduces nursing time in constantly readjusting flow rates.


  • Disadvantages



    • Usually requires special tubing.


    • There may be added cost to therapy.


    • Infusion pumps will continue to infuse despite the presence of infiltration (pump alarms for mechanical problems, not physiological problems).


  • Nursing responsibilities



    • Remember that a mechanical infusion regulator is only as effective as the nurse operating it.


    • Continue to check the patient regularly for complications, such as infiltration or infection.


    • Follow the manufacturer’s instructions carefully when inserting the tubing.


    • Double-check the flow rate.


    • Be sure to flush all air out of the tubing before connecting it to the patient’s IV catheter.


    • Explain the purpose of the device and the alarm system. Added machines in the room can evoke greater anxiety in the patient and family.


Types



  • Electronic flow rate regulators



    • These devices deliver a prescribed fluid volume per hour.


    • Often, pressure gradients may be adjusted so that high pressures are not used to deliver peripheral therapies.


    • Use of an electronic flow-rate regulator is indicated for continuous infusions of:



      • Chemotherapy.


      • Infant and pediatric therapies.


      • Hyperalimentation.


      • Fluid and electrolytes on patients at risk for fluid overload.


      • Most medications.


  • Battery-powered ambulatory infusion pumps



    • Example: CADD PRISMTM pump (Pharmacia Deltec, Inc.).


    • These pumps deliver continuous or intermittent medications by way of IV, subcutaneous, or spinal routes.


    • If used for pain control, patient may deliver a “bolus” injection if relief is not obtained from continuous, prescribed dose.


  • Freon-controlled spring pump (implanted)



    • Example: InfusaidTM (Neuromed).


    • Placed subcutaneously, usually in the left lower quadrant of the abdomen.


    • Will deliver continuous pain medication or chemotherapy by way of an artery, vein, or the spinal canal.


  • Computer-programmable pump (implanted)



    • Example: SynchroMed pumpTM (Medtronic).


    • Same actions as above.


Intermittent Infusions

Intermittent IV infusions may be given through an intermittent access device (saline lock), “piggybacked” to a continuous IV infusion, or for long-term therapy through a venous access device. See Procedure Guidelines 6-2, 6-3, and 6-4, pages 89 to 92.


Intermittent Access Device (Saline Lock)



  • This intermittent infusion device permits the administration of periodic IV medications and solution without continuous fluid administration.


  • Many facilities do not use heparin solutions to keep short peripheral catheters open. A saline flush (2 mL) is administered and a clamp is tightened or the needle is withdrawn while injecting to create positive pressure and keep the vein open.


“Piggyback” IV Administration



  • Means of administering medication by way of the fluid pathway of an established primary infusion line.


  • Drugs may be given on an intermittent basis through a primary infusion.



  • When a check valve is present on the primary tubing, it:



    • Permits the primary infusion to flow after the medication has been administered.


    • Prevents air from entering the system.


    • Prevents secondary fluid from “running dry.”


    • Permits less mixing of primary fluid with secondary solution.


  • Use of an infusion pump or controller will permit rate changes between primary and secondary infusates.