Interferon Beta-1a(in ter feer’ on)
Avonex, Rebif, Rebif Rebidose
PREGNANCY CATEGORY C
Drug Classes
Immunomodulator
Interferon
MS drug
Therapeutic Actions
Interferons are produced by human leukocytes in response to viral infections and other stimuli; interferon beta-1a blocks replication of viruses and stimulates the host immunoregulatory activities. It is produced by Chinese hamster ovary cells.
Indications
MS—treatment of relapsing forms of MS to slow accumulation of physical disability and decrease frequency of clinical exacerbations
Contraindications and Cautions
Contraindicated with allergy to beta interferon, human albumin, or any components of product, lactation.
Use cautiously with chronic progressive MS, suicidal tendencies or mental disorders, cardiac disease, seizures, pregnancy.
Available Forms
Powder for injection—33 mcg (Avonex), prefilled syringe; 30 mcg/0.5 mL (Avonex); injection—8.8 mcg/0.2 mL, 22 mcg/0.5 mL, 44 mcg/0.5 mL (Rebif); prefilled syringe—8.8, 22, 44 mcg (Rebif Rebidose)
Dosages
Adults
30 mcg IM once per week (Avonex)—22 or 44 mcg subcutaneously 3 times per week (Rebif)—start with 8.8 mcg 3 times per week and titrate up over 5 wk to full dose of 22–44 mcg.
Pediatric patients
Safety and efficacy not established in patients younger than 18 yr.
Pharmacokinetics
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