Galantamine Hydrobromide(gah lan’ tah meen)
Razadyne, Razadyne ERDNC
PREGNANCY CATEGORY B
Drug Classes
Alzheimer disease drug
Cholinesterase inhibitor
Therapeutic Actions
Centrally acting, selective, long-acting, reversible cholinesterase inhibitor; causes elevated acetylcholine levels in the cortex, which is thought to slow the neuronal degradation that occurs in Alzheimer disease.
Indications
Treatment of mild to moderate dementia of the Alzheimer type
Unlabeled use: Vascular dementia
Contraindications and Cautions
Contraindicated with allergy to galantamine, severe hepatic impairment, severe renal impairment.
Use cautiously with moderate renal or hepatic impairment, GI bleeding, seizures, asthma, COPD, pregnancy, lactation, and CV conditions.
Available Forms
Tablets—4, 8, 12 mg; oral solution with dosing syringe—4 mg/mL; ER capsulesDNC—8, 16, 24 mg
Dosages
Adults
Initially, 4 mg PO bid. If well tolerated after 4 wk, increase to 8 mg PO bid. If well tolerated after 4 more wk, increase to 12 mg PO bid. Range: 16–32 mg/day in two divided doses; ER capsules—initial dose, 8 mg/day PO; titrate to 16–24 mg/day PO.
Pediatric patients
Safety and efficacy not established.
Patients with hepatic or renal impairment
Do not exceed 16 mg/day. Contraindicated if CrCl less than 9 mL/min or if Child-Pugh score is 10–15.
Pharmacokinetics
|
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
