Flurbiprofen(flure bi’ proe fen)
Ophthalmic solution: Ocufen
Oral: Ansaid, Apo-Flurbiprofen (CAN)
PREGNANCY CATEGORY B (ORAL), C (OPHTHALMIC)
Drug Classes
Analgesic (nonopioid)
Anti-inflammatory
NSAID
Therapeutic Actions
Analgesic, anti-inflammatory, and antipyretic activities largely related to inhibition of cyclo-oxygenase and prostaglandin synthesis; exact mechanisms of action are not known.
Indications
Oral: Acute or long-term treatment of the signs and symptoms of rheumatoid arthritis and osteoarthritis
Oral: Relief of moderate to mild pain
Ophthalmic solution: Inhibition of intraoperative miosis
Unlabeled uses of ophthalmic solution: Topical treatment of cystoid macular edema, inflammation after cataract surgery and uveitis syndromes; oral—juvenile rheumatoid arthritis, sunburn, migraine headache
Contraindications and Cautions
Contraindicated with allergy to aspirin, flurbiprofen, or other NSAIDs, significant renal impairment, pregnancy, lactation.
Use cautiously with impaired hearing, allergies, hepatic, CV, and GI conditions.
Available Forms
Tablets—50, 100 mg; ophthalmic solution—0.03%
Dosages
Adults
Oral
Initial recommended daily dose of 200–300 mg PO, give in divided doses bid, tid, or qid. Largest recommended single dose is 100 mg. Doses above 300 mg/day PO are not recommended. Taper to lowest possible dose.
Ophthalmic solution
Instill 1 drop approximately every 30 min, beginning 2 hr before surgery (total of 4 drops).
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