Ezogabine(ee zog’ a been)
Potiga
PREGNANCY CATEGORY C
Drug Classes
Antiepileptic
Potassium channel opener
Therapeutic Actions
Enhances transmembrane potassium currents, leading to stabilization of the resting membrane potential and reducing brain excitability; may also augment GABA effects.
Indications
Adjunct treatment of partial-onset seizures in adults who have responded inadequately to several alternative treatments and for whom benefits outweigh risk of potential visual damage
Contraindications and Cautions
Contraindicated with history of serious hypersensitivity reactions to ezogabine.
Use cautiously with urine retention, prolonged QT interval, pregnancy, lactation.
Available Forms
Tablets—50, 200, 300, 400 mg
Dosages
Adults
100 mg PO tid for 1 wk; titrate to maintenance dose of 200–400 mg PO tid at weekly intervals by no greater than 50 mg tid each wk.
Geriatric patients, patients with renal impairment
Initially, 50 mg PO tid; increase by no more than 50 mg tid at weekly intervals. Target dose, 250 mg PO tid for elderly patients, 200 mg PO tid for patients with renal impairment (CrCl less than 50 mL/min).
Pharmacokinetics
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