Dangerous Drug: Promethazine Hydrochloride



Dangerous Drug: Promethazine Hydrochloride





(proe meth’ a zeen)

Histanal (CAN), Phenadoz, Phenergan, PMS-Promethazine (CAN), Promethegan

PREGNANCY CATEGORY C


Drug Classes

Antiemetic

Antihistamine

Anti–motion-sickness drug

Dopaminergic blocker

Phenothiazine

Sedative-hypnotic


Therapeutic Actions

Selectively blocks histamine-1 receptors, diminishing the effects of histamine on cells of the upper respiratory tract and eyes and decreasing the sneezing, mucus production, itching, and tearing that accompany allergic reactions in sensitized people exposed to antigens; blocks cholinergic receptors in the vomiting center that are believed to mediate the nausea and vomiting caused by gastric irritation, by input from the vestibular apparatus (motion sickness, nausea associated with vestibular neuritis), and by input from the chemoreceptor trigger zone (drug- and radiation-induced emesis); depresses the RAS, including the parts of the brain involved with wakefulness.


Indications



  • Symptomatic relief of perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis; mild, uncomplicated urticaria and angioedema; amelioration of allergic reactions to blood or plasma; dermatographism, adjunctive therapy (with epinephrine and other measures) in anaphylactic reactions


  • Treatment and prevention of motion sickness; prevention and control of nausea and vomiting associated with anesthesia and surgery


  • Preoperative, postoperative, or obstetric sedation


  • Adjunct to analgesics to control postoperative pain


  • Adjunctive IV therapy with reduced amounts of meperidine or other opioid analgesics in special surgical situations, such as repeated bronchoscopy, ophthalmic surgery, or in poor-risk patients


  • Unlabeled uses: Treatment of nausea and vomiting in pregnancy, opioid-induced nausea and vomiting



Available Forms

Tablets—12.5, 25, 50 mg; syrup—6.25 mg/5 mL; suppositories—12.5, 25, 50 mg; injection—25, 50 mg/mL


Dosages

Adults

Jul 21, 2016 | Posted by in NURSING | Comments Off on Dangerous Drug: Promethazine Hydrochloride

Full access? Get Clinical Tree

Get Clinical Tree app for offline access