Dangerous Drug: Oxymorphone Hydrochloride



Dangerous Drug: Oxymorphone Hydrochloride





(ox i mor’ fone)

Opana, Opana ERDNC

PREGNANCY CATEGORY C

CONTROLLED SUBSTANCE C-II


Drug Class

Opioid agonist analgesic


Therapeutic Actions

Semisynthetic derivative of morphine. Acts as agonist at specific opioid receptors in the CNS to produce analgesia, euphoria, sedation; the receptors mediating these effects are thought to be the same as those mediating the effects of endogenous opioids (enkephalins, endorphins).


Indications



  • Relief of moderate to moderately severe acute pain (immediate-release form)


  • Parenterally (injection only) for preoperative medication, support of anesthesia, obstetric analgesia


  • Relief of moderate to severe pain in patients who need around-the-clock opioid treatment for extended time (ER form)


  • Relief of anxiety in patients with pulmonary edema associated with left ventricular dysfunction (parenteral)


  • Relief of moderate to severe pain



Available Forms

Injection—1 mg/mL; tablets—5, 10 mg; ER tabletsDNC—5, 7.5, 10, 20, 30, 40 mg


Dosages

Adults

Oral

For immediate-release form, 10–20 mg PO every 4–6 hr. For ER tablets, 5 mg PO every 12 hr; may be increased in 5- to 10-mg increments every 3–7 days to cover pain.

IV

Initially, 0.5 mg IV.

Subcutaneous or IM

Initially, 1–1.5 IM or subcutaneously mg every 4–6 hr as needed. For analgesia during labor, 0.5–1 mg IM.

Pediatric patients

Safety and efficacy not established for children younger than 18 yr.

Geriatric patients or impaired adults

Use caution; respiratory depression may occur in the elderly, the very ill, and those with respiratory problems. Start at low end of dosage range and titrate slowly.

Patients with renal impairment

For CrCl of less than 50 mL/min, use ER tablets at lowest possible dose.


Pharmacokinetics
































Route Onset Peak Duration
Oral (ER) 15–30 min 60 min 8–10 hr
Oral (immedi-ate-release) 5–10 min 1 hr 3–6 hr
IV 5–10 min 15–60 min 3–6 hr
IM, Subcut. 10–15 min 30–60 min 3–6 hr

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Jul 21, 2016 | Posted by in NURSING | Comments Off on Dangerous Drug: Oxymorphone Hydrochloride

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