Dangerous Drug: Oxycodone Hydrochloride(ox i koe’ done)
M-oxy, OxectaDNC, OxyContinDNC, OxyFAST, OxyIR, Roxicodone, Roxicodone Intensol, Supeudol (CAN)
PREGNANCY CATEGORY B
CONTROLLED SUBSTANCE C-II
Drug Class
Opioid agonist analgesic
Therapeutic Actions
Acts as agonist at specific opioid receptors in the CNS to produce analgesia, euphoria, sedation; the receptors mediating these effects are thought to be the same as those mediating the effects of endogenous opioids (enkephalins, endorphins).
Indications
Relief of moderate to moderately severe pain
CR tablets: Management of moderate to severe pain when a continuous, around-the-clock analgesic is needed for an extended period of time
Contraindications and Cautions
Contraindicated with hypersensitivity to opioids; diarrhea caused by poisoning (before toxins are eliminated); pregnancy (readily crosses placenta; neonatal withdrawal); labor or delivery (opioids given to the mother can cause respiratory depression in neonate; premature infants are at special risk; may prolong labor); bronchial asthma, COPD, cor pulmonale, respiratory depression, anoxia; kyphoscoliosis; acute alcoholism, increased intracranial pressure, lactation.
Use cautiously with acute abdominal conditions, CV disease, supraventricular tachycardias, myxedema, seizure disorders, delirium tremens, cerebral arteriosclerosis, ulcerative
colitis, fever, Addison disease, prostatic hypertrophy, urethral stricture, recent GI or GU surgery, toxic psychosis, renal or hepatic impairment.
Available Forms
Immediate-release capsules—5 mg; immediate-release tablets—5, 10, 15, 20, 30 mg; CR tabletsDNC—10, 15, 20, 30, 40, 60, 80 mg; oral solution—5 mg/5 mL; solution concentrate—20 mg/mL; tablets in aversion technologyDNC—5, 7.5 mg
Dosages
Individualize dosage.
Adults
Immediate-release tablets: 5–15 mg PO every 4–6 hr; opioid-naïve patients, 10–30 mg PO every 4 hr. Use lowest dosage that achieves adequate pain relief. For chronic pain, administer on a regular schedule every 4–6 hr. Discontinue gradually.
Immediate-release capsules: 5 mg PO every 6 hr.
Immediate-release tablets in aversion technology: 5–15 mg PO every 4 hr as needed.
Oral solution: 10–30 mg PO every 4 hr as needed. For chronic pain, give regularly every 4–6 hr at lowest dosage needed to relieve pain.
CR tablets: Initially, 10 mg PO every 12 hr for patients taking nonopioid analgesics and requiring around-the-clock therapy for an extended period of time. Adjust dosage every 1–2 days as needed by increasing dose by 25% to 50%.
Breakthrough pain: Immediate-release (OxyIR): 5 mg PO every 4 hr.
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