Dangerous Drug: Milrinone Lactate(mill’ ri none)
Primacor (CAN)
PREGNANCY CATEGORY C
Drug class
Inotropic
Therapeutic Actions
Increases force of contraction of ventricles (positive inotropic effect); causes vasodilation by a direct relaxant effect on vascular smooth muscle.
Indications
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Heart failure: Short-term IV management of patients with acute decompensated heart failure
NEW INDICATION: Unlabeled use: Augmentation of cardiac output in patients after cardiac arrest
Contraindications and Cautions
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Contraindicated with allergy to milrinone or bisulfites; severe aortic or pulmonic valvular disease.
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Use cautiously in the elderly, and with pregnancy, lactation.
Available Forms
Injection—1 mg/mL; premixed injection—0.2 mg/mL
Dosages
Adults
Loading dose, 50 mcg/kg IV bolus, given over 10 min. Maintenance infusion, 0.375–0.75 mcg/kg/min. Do not exceed a total of 1.13 mg/kg/day.
Pediatric patients
Not recommended.
Patients with renal impairment
Do not exceed 1.13 mg/kg/day. For patients with renal impairment, refer to this table:
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