Patient should pick a date to stop smoking and begin drug therapy 1 wk before that date; or patient can begin drug and quit smoking between days 8 and 35 of treatment.

Days 1–3, 0.5 mg/day PO; days 4–7, 0.5 mg PO bid; day 8 until the end of treatment, 1 mg PO bid. Drug should be taken after eating with a full glass of water. Treatment should last 12 wk; patients who successfully quit smoking in that time may benefit from another 12 wk to increase the likelihood of long-term abstinence. Patients who fail to quit smoking during the 12 wk or who relapse after treatment can be treated again when factors leading to failed attempt have been identified and addressed.

Safety not established for children younger than 18 yr.

Initially, 0.5 mg/day PO; titrate to 0.5 mg PO bid. If on dialysis, 0.5 mg/day.