Brompheniramine Maleate (Parabromdylamine Maleate)(brome fen ir’ a meen mal’ ee ate)
BroveX, J-Tan, LoHist 12 HourDNC, P-Tex, Respa A.R., VaZol
PREGNANCY CATEGORY C
Drug class
Antihistamine (alkylamine type)
Therapeutic Actions
Competitively blocks the effects of histamine at H1-receptor sites; has anticholinergic (atropine-like), antipruritic, and sedative effects.
Indications
Symptomatic relief of symptoms associated with perennial and seasonal allergic rhinitis—runny nose, sneezing, itching nose and throat, watery eyes
Temporary relief of sneezing and runny nose due to common cold; treatment of allergic and nonallergic pruritic symptoms; mild urticaria and angioedema; amelioration of allergic reactions to blood or plasma; adjunctive therapy in anaphylactic reactions (VaZol)
Contraindications and Cautions
Contraindicated with allergy to any antihistamines, third trimester of pregnancy (newborn or preterm infants may have severe reactions); patients receiving MAOIs, alcohol.
Use cautiously with lactation, narrow-angle glaucoma, stenosing peptic ulcer, symptomatic prostatic hypertrophy, asthma attack, bladder neck obstruction, pyloroduodenal obstruction. Use cautiously in the elderly (this population is extremely sensitive to anticholinergic side effects of this drug).
Available Forms
Chewable tablets—12 mg; ER tabletsDNC—6 mg; ER capsulesDNC—12 mg; drops—1 mg; liquid—1 mg/mL, 2 mg/5 mL; oral suspension—4 mg/5 mL, 8 mg/5 mL, 10 mg/5 mL, 12 mg/5 mL
Dosages
Adults and pediatric patients 12 yr and older
Products vary widely. Check manufacturer’s instructions before use. ER tablets: 6–12 mg PO every 12 hr. Chewable tablets: 12–24 mg PO every 12 hr, maximum 48 mg/day. ER capsules: 12–24 mg/day PO. Oral suspension (BroveX): 5–10 mL (12–24 mg) PO every 12 hr; maximum 48 mg/day. Oral liquid: 10 mL (4 mg) PO 4 times/day. Oral suspension: 5 mL PO every 12 hr; do not exceed 2 doses/day.
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
