Transfusion reactions

Reaction and causes	Signs and symptoms
Allergic Allergen in donor blood Donor blood hypersensitive to certain drugs	Anaphylaxis (chills, facial swelling, laryngeal edema, pruritus, urticaria, wheezing), fever, nausea, and vomiting
Bacterial contamination Organisms that can survive cold, such as Pseudomonas and Staphylococcus	Chills, fever, vomiting, abdominal cramping, diarrhea, shock, signs of renal failure
Febrile Bacterial lipopolysaccharides Antileukocyte recipient antibodies directed against donor white blood cells	Temperature up to 104° F (40°C), chills, headache, facial flushing, palpitations, cough, chest tightness, increased pulse rate, flank pain
Hemolytic ABO or Rh incompatibility Intradonor incompatibility Improper crossmatching Improperly stored blood	Chest pain, dyspnea, facial flushing, fever, chills, shaking, hypotension, flank pain, hemoglobinuria, oliguria, bloody oozing at the infusion site or surgical incision site, burning sensation along vein receiving blood, shock, renal failure
Plasma protein incompatibility Immunoglobulin-A incompatibility	Abdominal pain, diarrhea, dys-pnea, chills, fever, flushing, hypo-tension

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