Condition in which the pregnant woman is Rh negative but her fetus is Rh positive

If left untreated, isoimmunization can lead to hemolytic disease in the newborn

Before the development of Rh_o(D) immune globulin (human), this condition was a major cause of kernicterus and neonatal death (see Pathogenesis of Rh isoimmunization, page 70)

Also known as Rh sensitivity