Torsemide(tor’ seh myde)
Demadex
PREGNANCY CATEGORY B
Drug Classes
Loop (high-ceiling) diuretic
Sulfonamide
Therapeutic Actions
Inhibits the reabsorption of sodium and chloride from the proximal and distal renal tubules and the loop of Henle, leading to a natriuretic diuresis.
Indications
Treatment of hypertension and edema associated with HF, hepatic cirrhosis, renal failure
Contraindications and Cautions
Contraindicated with allergy to torsemide; known hypersensitivity to sulfonylureas; anuria, severe renal failure; hepatic coma.
Use cautiously with SLE, electrolyte depletion, gout, diabetes mellitus, lactation, pregnancy.
Available Forms
Tablets—5, 10, 20, 100 mg; injection—10 mg/mL
Dosages
Adults
Warning Do not exceed 200 mg/day.
HF: 10–20 mg PO or IV daily. Dose may be titrated upward by doubling the dose until desired results are seen. Do not exceed 200 mg/day.
Chronic renal failure: 20 mg PO or IV daily. Dose may be titrated upward by doubling the dose until desired results are seen. Do not exceed 200 mg/day.
Hepatic failure: 5–10 mg PO or IV daily. Do not exceed 40 mg/day.
Hypertension: 5 mg PO daily. May be increased to 10 mg if response is not sufficient.
Pediatric patients
Safety and efficacy not established.
Pharmacokinetics
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