Tiagabine Hydrochloride(tye ag’ ah bine)
Gabitril Filmtabs
PREGNANCY CATEGORY C
Drug class
Antiepileptic
Therapeutic Actions
Increases GABA levels in the brain, which may result in antiseizure effects. GABA is the major inhibitory neurotransmitter in the CNS; tiagabine binds to GABA reuptake sites, preventing its reuptake, and increases levels in the presynaptic neurons and the glia.
Indications
Adjunctive therapy in patients older than 12 yr with partial seizures
Unlabeled uses: Bipolar disorders, PTSD; refractory seizures in children; insomnia.
Contraindications and Cautions
Contraindicated with hypersensitivity to tiagabine, hepatic disease or significant hepatic impairment.
Use cautiously with pregnancy, lactation, and the elderly.
Available Forms
Tablets—2, 4, 12, 16 mg
Dosages
Adults
4 mg PO daily for 1 wk; may be increased by 4–8 mg/wk until desired response is seen; maximum dose, 56 mg/day in two to four divided doses. Usual maintenance dose is 32–56 mg PO daily.
Pediatric patients 12–18 yr
4 mg PO daily for 1 wk; may be increased to 8 mg/day in two divided doses for 1 wk; then increased by 4–8 mg/wk up to a maximum of 32 mg/day PO in two to four divided doses.
Pediatric patients younger than 12 yr
Not recommended.
Pharmacokinetics
|
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
