The Client Receiving Treatment for Neoplastic Disorders

CHAPTER 14


The Client Receiving Treatment for Neoplastic Disorders



CHEMOTHERAPY


This care plan focuses on the use of cytotoxic drugs (chemotherapeutic agents) in the treatment of cancer. Chemotherapy is used alone or in combination with radiation therapy, surgery, and/or biotherapy to achieve a cure, control tumor growth, or provide relief of symptoms associated with advanced disease (palliation). Success of the therapy depends on the size, type, and location of the tumor in addition to the client’s physiological and psychological condition.


Cytotoxic drugs are classified according to chemical structure (e.g., antimetabolites, mitotic inhibitors [vinca alkaloids, plant alkaloids], alkylating agents), primary mode of action (e.g., interfere with folic acid synthesis, produce cross-links of DNA strands), or effect on the cell life cycle. Some drugs are more effective during a specific phase of the cell cycle and are referred to as cell cycle phase-specific or cell cycle-specific (e.g., mitotic inhibitors, antimetabolites). The cytotoxic agents that interrupt the cell replication process without regard to the phase of the cell cycle are classified as cell cycle phase-nonspecific or cell cycle-nonspecific (e.g., alkylating agents, antitumor antibiotics).


The primary effect of cytotoxic drugs is to interrupt cell replication. It is believed that cytotoxic drugs kill a fixed percentage, rather than a specific number, of tumor cells with each dose and that tumors with a large percentage of growing cells will experience greater cell death than tumors with a smaller percentage of growing cells. Cells in the resting phase are less responsive to chemotherapeutic agents and are better able to repair themselves if damaged during treatment.


The finding that tumor cells may develop resistance to chemotherapeutic agents has resulted in the development of multiple drug protocols in which a combination of drugs is given simultaneously or in a particular sequence. The additive and sometimes synergistic effects that occur when drugs are used together allow an increased percentage of tumor cell kill without a concomitant increase in drug-induced toxicities. The dose, combination, and treatment schedule for the drugs are determined by factors such as the physiological status of the client and the drug’s action on the cell cycle, metabolism, toxic effects, and nadir. Cytotoxic agents are most frequently given intravenously, but routes such as oral, subcutaneous, topical, and direct instillation into the target area (e.g., peritoneum, bladder, cerebrospinal fluid) are used when appropriate.


Cytotoxic drugs do not discriminate between the normal and the cancerous cell and, as a result, the client may experience certain side effects and/or toxic effects after their administration. The drugs have the greatest effect on rapidly dividing cancerous and normal cells (e.g., bone marrow, skin, hair follicles, lining of the gastrointestinal tract). Because of this lack of selectivity between the cancerous and the normal cell, nursing care of the recipient of the drugs is indeed a challenge.


This care plan focuses on the adult client hospitalized for an initial or subsequent cycle of chemotherapy and/or management of side effects of treatment with cytotoxic agents. Much of the information is applicable to clients receiving chemotherapy and/or follow-up care in an outpatient facility or home setting.



OUTCOME/DISCHARGE CRITERIA


The client will:



1. Have no signs and symptoms of toxic effects of cytotoxic agents


2. Have side effects of cytotoxic agents under control


3. Have fatigue at a manageable level


4. Have an adequate or improved nutritional status


5. Identify ways to prevent infection during periods of lowered immunity


6. Demonstrate appropriate oral hygiene techniques


7. Identify techniques to control nausea and vomiting


8. Verbalize ways to improve appetite and nutritional status


9. Verbalize ways to manage and cope with persistent fatigue


10. Verbalize ways to prevent bleeding when platelet counts are low


11. Verbalize ways to adjust to alterations in reproductive and sexual functioning


12. Verbalize ways to promote independence and prevent injury if neuropathies are present


13. Demonstrate the ability to care for a central venous catheter, a peritoneal catheter, or an implanted infusion device if in place


14. Verbalize an understanding of the care and precautions necessary if an Ommaya reservoir is in place


15. Verbalize an understanding of an implanted infusion pump and precautions necessary if one is in place


16. State signs and symptoms to report to the health care provider


17. Share thoughts and feelings about changes in body image resulting from chemotherapy


18. Identify community resources that can assist with home management and adjustment to the diagnosis of cancer and chemotherapy and its effects


19. Verbalize an understanding of and a plan for adhering to recommended follow-up care including medications prescribed and schedule for chemotherapy, laboratory studies, and future appointments with health care provider



Nursing Diagnosis IMBALANCED NUTRITION: LESS THAN BODY REQUIREMENTS NDx


Definition: Intake of nutrients insufficient to meet metabolic needs


Related to:



• Decreased oral intake associated with:



• Loss of nutrients associated with vomiting and diarrhea if present


• Impaired utilization of nutrients associated with:



• Utilization of available nutrients by the malignant cells rather than the host












Nursing Diagnosis ACUTE/CHRONIC PAIN NDx


Definition: Pain is an unpleasant sensory and emotional experience arising from actual or potential tissue damage, or described in terms of such damage.


Acute: sudden or slow onset of pain in any intensity from mild to severe with anticipated or predictable end and a duration of less than 6 months


Chronic: sudden or slow onset of pain of any intensity from mild to severe, constant or recurring without anticipated or predictable end and a duration of greater than 6 months


Related to:













Nursing Diagnosis IMPAIRED ORAL MUCOUS MEMBRANE NDx


Definition: Disruption of lips and soft tissue of the oral cavity


Related to:


Dryness related to reduced oral intake


Stomatitis related to:







Collaborative Diagnosis RISK FOR BLEEDING


Definition: Escape of blood from an injured vessel.


Related to: Thrombocytopenia associated with chemotherapy-induced bone marrow suppression










Collaborative Diagnosis RISK FOR IMPAIRED RENAL FUNCTION


Definition: Inability of the kidney to appropriately concentrate urine and excrete waste products


Related to:




Feb 11, 2017 | Posted by in NURSING | Comments Off on The Client Receiving Treatment for Neoplastic Disorders

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