Sulindac(sul in’ dak)
Apo-Sulin (CAN), Clinoril
PREGNANCY CATEGORY B (FIRST AND SECOND TRIMESTERS)
PREGNANCY CATEGORY D (THIRD TRIMESTER)
Drug Classes
Analgesic
Antipyretic
NSAID
Therapeutic Actions
Anti-inflammatory, analgesic, and antipyretic activities largely related to inhibition of prostaglandin synthesis; exact mechanisms of action are not known.
Indications
Acute or long-term use to relieve signs and symptoms of osteoarthritis, rheumatoid arthritis, acute gouty arthritis
Acute or long-term use in relief of signs and symptoms of ankylosing spondylitis, acute painful shoulder
Unlabeled use: Treatment of juvenile rheumatoid arthritis
Contraindications and Cautions
Contraindicated for perioperative pain in coronary artery bypass graft (CABG) surgery and in late pregnancy, lactation.
Use cautiously with patients for whom acute asthmatic attacks, urticaria, or rhinitis are precipitated by aspirin or other NSAIDs, renal, hepatic, CV, and GI conditions.
Available Forms
Tablets—150, 200 mg
Dosages
Do not exceed 400 mg/day.
Adults
Rheumatoid arthritis or osteoarthritis, ankylosing spondylitis: Initial dose of 150 mg bid PO; maximum dose, 400 mg/day. Individualize dosage.
Acute painful shoulder, acute gouty arthritis: 200 mg bid PO; maximum dose, 400 mg/day. After adequate response, reduce dosage. Acute painful shoulder usually requires 7–14 days of therapy; acute gouty arthritis, 7 days.
Pediatric patients
Safety and efficacy not established.
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