Substance-Related Disorders

Chapter 9. Substance-Related Disorders




BOX 9-1




DRUGS OF ABUSE






▪ Alcohol


▪ Amphetamines


▪ Other sympathomimetics


▪ Caffeine


▪ Cannabis


▪ Nicotine


▪ Cocaine


▪ Hallucinogens


▪ Inhalants


▪ Opioids


▪ Phencyclidine (PCP)


▪ Sedatives/hypnotics/anxiolytics


MEDICATIONS






▪ Anesthetics


▪ Analgesics


▪ Anticholinergics


▪ Anticonvulsants


▪ Antihistamines


▪ Antihypertensives


▪ Cardiovascular agents


▪ Antiparkinson agents


▪ Antimicrobials


▪ Antidepressants


▪ NSAIDs


▪ Over-the-counter medications


TOXINS






▪ Heavy metals (lead)


▪ Rat poison


▪ Pesticides


▪ Nerve gases


▪ Antifreeze


▪ Carbon monoxide


▪ Carbon dioxide


▪ Fuel


▪ Paint

NSAIDs, Nonsteroidal antiinflammatory drugs.




▪ Drugs of abuse


▪ Medications


▪ Toxins


DRUGS OF ABUSE


Several substances have been used intentionally by people throughout recorded history, and most likely before that time, for the purpose of altering their minds, bodies, perceptions, thoughts, and moods. Legal and illegal recreational drug use continues to be widespread in many countries of the world, including the United States of America. Effects of substance use are manifested in physical, mental, and emotional symptoms. The abuse of drugs has the potential to disrupt not only the lives of individuals who use them, but also lives of their families, friends, employers, and society in general, who also pay a price in multiple ways.

Examples are evident in every area of life: physical illnesses and diseases (HIV/AIDS, cirrhosis of the liver, fetal alcohol syndrome), mental disorders (substance-induced persisting psychosis), substance-induced persisting dementia, social impairment (substance-related divorce, or alienation by family), legal problems (drug-related injury to others, DUI sentences), and occupational problems (terminated from job, expelled from school). For some individuals the intentional use of substances may be controlled and considered relatively harmless. Many others, however, experience a loss of control over use of substances, which often results in disruptive disorders, the focus of this chapter.


ETIOLOGY


Despite the physical, emotional, cognitive, social, relational, occupational, spiritual, and legal problems that may occur as a result of substance abuse and dependence, many individuals continue to use and abuse drugs. Theories to describe this compelling phenomenon are plentiful, but none is solely accepted. As with many other categories of psychiatric disorders, it is widely accepted that a combination of biologic, psychologic, psychosocial, and environmental factors converge to perpetuate substance-related disorders.


BOX 9-2




BIOLOGIC






▪ Genetic predisposition


▪ Neurobiologic origins




▪ Low levels of MAOIs


▪ Dehydrogenase deficit


▪ Dopamine excess/cravings


▪ Comorbid physical/mental diagnoses


▪ Self-care need/interest deficit


PSYCHOLOGIC/BEHAVIORAL






▪ Depressed mood


▪ Unmet dependency needs


▪ Impulsive style


▪ Inability to tolerate failure


▪ Inability to contend with life stress


▪ Unmet needs for power/attention


▪ Hyperactivity or conduct disorder


▪ Low self-concept/self-esteem


▪ Codependence


SOCIAL






▪ Peer influence/pressure


▪ Detrimental environment




▪ Deteriorating neighborhood


▪ Alienating issues


▪ Illegal behaviors


▪ Drug trafficking


▪ Dysfunctional family system

MAOIs, Monoamine oxidase inhibitors.

*Etiology is attributed to a combination of biologic, psychologic, psychosocial, and environmental factors.


EPIDEMIOLOGY


Cannabis (marijuana), often referred to as the “gateway drug” because it is frequently the first or one of the first drugs that young people use, is one of the most commonly abused drugs in America, followed by abuse of prescription drugs.

Although alcohol abuse and dependence remain a major problem in the United States because alcohol is readily available, legal, and relatively inexpensive, alcohol use has decreased slightly over the past 2 decades. Several factors influenced this trend, but the most salient reasons appear to be the swift and sure legal consequences for driving while intoxicated, a growing public intolerance for drunkenness, and the focus on increased health and fitness, which is incongruent with heavy alcohol consumption.

All age groups may be affected by drug abuse. The prevalence of alcohol and drug abuse is higher among men than women, although women abuse prescription drugs more often. Men ages 30 to 45 have the highest abuse rates. Heavy alcohol use across a lifetime is reported by approximately 25% of U.S. adults, and 15% report heavy abuse of other drugs. The fastest growing population of drug abusers is the elderly.



Raves


A continuing trend among young people is an increase of drug sales and drug consumption during parties called “raves” and entertainment in commercial dance clubs. Frequently, uninformed parents condone their children’s participation at these venues because they usually include dancing and are often advertised as being alcohol-free. Naïve parents may think their children will be safe. In addition, the need for approval in this developmental stage is strong, and as a result, many youngsters who ordinarily would not try drugs bow to peer pressure when they are encouraged and/or challenged.

The drugs that are abundantly available at these gatherings are dangerous, and the number of fatalities rises each year. Danger exists not only in the chemical compounds but in the inconsistency of the product’s content. Users most often do not know the source, strength, or safety of the drugs but use them anyway. The drugs are also referred to as “club drugs,” “designer drugs,” or as the media calls them “date-rape drugs” because some of them cause amnesia along with other varied symptoms and render their users helpless, easy targets for sexual abuse.

These drugs are considered illegal in some states and include the following:




Ecstasy (MDMA, “E”), a synthetic stimulant, is one of the most popular club drugs. It was considered safe and used widely by drug users in the 1970s. It is cheap to make and is usually imported from Europe, mainly the Netherlands, where it is legal. Dealers can get $15 to $30 per pill here in the United States, so one understands the difficulty stopping sales.


GHB (gamma hydroxybutyrate, “liquid ecstasy”) was legally used in this country as a muscle building compound but is no longer legally available. Its intoxicating effects are similar to alcohol, and it is often touted as the “date-rape drug” because it is a clear liquid that can easily be and often is added to the drinks of unsuspecting victims.


Ketamine (“K,” “Special K”) is an animal tranquilizer used by veterinarians that causes hallucinations in humans. It is often used with Ecstasy and other drugs. The combining of club drugs is called “cocktailing” or “rolling.” Mixing drugs may potentiate the effects and increase the dangers.


Nitrous oxide (NO) is a gas that is legally used by dentists and other medical professionals for anesthesia. Partygoers use the drug by filling balloons with the gas and rebreathing it (inhaling and exhaling into the balloon) until their brain oxygen is depleted, causing altered sensations and consciousness and often unconsciousness.

Most state governing bodies are aware of this problem and act to curtail it, but many argue that laws will not stop the drug use in this population.


Comorbidity





























































































































































TABLE 9-1 Diagnoses Associated with Class of Substances
From American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision, Washington, DC, 2000, American Psychiatric Association. © American Psychiatric Association2000
N ote: X, I, W, I/W, or P indicates that the category is recognized in DSM-IV-TR. In addition, I indicates that the specifier With Onset During Intoxication may be noted for the category (except for Intoxication Delirium); W indicates that the specifier With Onset During Withdrawal may be noted for the category (except for Withdrawal Delirium); and I/W indicates that either With Onset During Intoxication or With Onset During Withdrawal may be noted for the category. P indicates that the disorder is Persisting.
*Also hallucinogen persisting perception disorder (flashbacks).
From American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision, Washington, DC, 2000, American Psychiatric Association.

Dependence Abuse Intoxication Withdrawal Intoxication Delirium Withdrawal Delirium Dementia Amnestic Disorder Psychotic Disorder Mood Disorders Anxiety Disorders Sexual Dysfunctions Sleep Disorders
Alcohol X X X X I W P P I/W I/W I/W I I/W
Amphetamines X X X X I I I/W I I I/W
Caffeine X I I
Cannabis X X X I I I
Cocaine X X X X I I I/W I/W I I/W
Hallucinogens X X X I I* I I
Inhalants X X X I P I I I
Nicotine X X
Opioids X X X X I I I I I/W
Phencyclidine X X X I I I I
Sedatives
Hypnotics or Anxiolytics X X X X I W P P I/W I/W W I I/W
Polysubstance X
Other X X X X I W P P I/W I/W I/W I I/W


ASSESSMENT AND DIAGNOSTIC CRITERIA




Substance Abuse


The defining characteristic of substance abuse is at least a 12-month pattern of maladaptive, continuous, or recurrent substance use that results in one or more of the following:




1. Failure to complete obligations in home (neglect family), work (take excess absences), or school (fail to complete assignments/get expelled)


2. Continued use of substances despite danger (driving while intoxicated)


3. Legal problems occur as a result of substance intake (DUI; arrest for threatening neighbor while intoxicated)


4. Recurrent social or interpersonal problems (friends stop inviting person, arguments with spouse about drug use).


Substance Dependence


The defining characteristic of substance dependence is continued use of substance(s) despite substance-related problems, as evidenced by physiologic, cognitive, and behavioral symptoms. The individual uses the substance(s) in a repeated pattern that can result in tolerance, withdrawal, and drug-taking behaviors that become compulsive. The person develops strong physical, psychologic, and behavioral drives to use the substance repeatedly. The presence of three or more of the following characteristics constitutes dependence:




1. Tolerance is the need for greater amounts of the substance to produce the desired effects (e.g., intoxication) or decreased effects when the same amount of substance is used over time.


2. Withdrawal refers to the physiologic, cognitive, and behavioral symptoms (a substance-specific syndrome) that occur when heavy use of substance(s) over a long period is stopped, and blood/tissue levels of the substance decline. In addition, the person usually takes the same or similar substance to relieve the symptoms of withdrawal.


3. Compulsive substance use pattern is characterized by the following:




a. The substance is used for longer than intended, or larger amounts are needed.


b. The person continually wants to stop or decrease use, and the individual tries but fails.


c. More and more time is devoted to obtaining, using, or recovering from the drug.


d. Substance use takes the place of previous activities (recreation, work, family/friends).


e. Use of substances continues despite, physical (cirrhosis, ulcers), legal (DUI, jail), and social/occupational problem (divorce, loss of job).


THE SUBSTANCES OF ABUSE



Alcohol



Physical, psychologic, and interpersonal dysfunction is a by-product of alcohol dependence. Alcoholism is a chronic disease and is the number-one drug problem in the United States that involves a legal substance.

The three major patterns of pathologic alcohol use are as follows:




1. Need for and consumption of large amounts daily


2. Regular and heavy weekend drinking


3. Long intervals of sobriety with intermittent heavy drinking binges that last weeks or months

Reports indicate an intergenerational familial pattern for alcoholism; members of an alcoholic family have a higher inborn tolerance for alcohol. Use and abuse of alcohol are often accompanied by use or abuse of additional psychoactive substances (polysubstance abuse). Nicotine dependence is a common accompaniment; other substances frequently used are cocaine, heroin, amphetamines, cannabis, sedatives, hypnotics, and anxiolytics.

Depression is often a concomitant disorder with alcohol dependence; however, the depression may be secondary to alcohol use, or individuals may drink to “fix” the dysphoria that is already present. Alcoholism and abuse of other substances are often complications in persons with bipolar disorder.


Amphetamines


Amphetamine is a CNS stimulant that is typically taken orally or inhaled but may also be injected. Use often begins for purposes of suppressing appetite or enhancing sexual activity and euphoria. Binges may be followed by a period when the individual is exhausted, depressed, irritable, anergic, and withdrawn (“crash”). Paranoia, sexual dysfunction, memory, and attention disturbances are also common with amphetamine dependence. Tolerance to this drug may occur rapidly, resulting in an inability to experience euphoria and an increase of adverse symptoms.



Cannabis


The most common drugs in this group are marijuana, hashish, and purified THC (tetrahydrocannabinol), which are usually smoked but may be ingested orally. Cannabis may produce euphoria, calmness, drowsiness, and oneiroid states (dreamlike states while awake) or anxiety, paranoia, and, in very high doses or with long-term use, hallucinations.

Dependence on cannabis can be insidious because (1) many users are able to continue to function socially and occupationally and (2) the physical disorders that may accompany other drugs (cocaine, alcohol, heroin) are relatively lacking. Major problems related to long-term marijuana use are (1) extreme amotivation that renders the individual unable or unwilling to attend to tasks that require persistence; (2) anxiety states; and (3) physical symptoms such as chronic respiratory diseases, impaired immune responses, and hormonal dysfunction.


Cocaine


Cocaine, legally classified as a narcotic, produces extreme euphoria, so psychologic dependence may occur after the first use. Cocaine can be inhaled, injected, or smoked (“crack” or “freebase”), and in some cultures it is chewed as coca leaves. The clinical effects of cocaine are similar to the effects of amphetamines, and in addition to euphoria the individual may experience increased task performance, both mental and physical, and increased self-esteem. Intoxication occurs rapidly and is followed by a “crash” caused by dramatic depletion of serotonin. Withdrawal brings symptoms of dysphoria, fatigue, irritability, and anxiety; resultant depression is often accompanied by suicidal ideation.

“Crack” or “rock” cocaine has been labeled one of the most addictive drugs and is even more insidious, addictive, and toxic than cocaine. Cardiac dysrhythmias, which are caused by cocaine use in all forms, may lead to death. The number of babies born to mothers who use crack is significant, and they are likely to be born prematurely and have low birth weight and numerous neurologic problems. They are also subject to abuse and neglect, a problem that is currently considered to be of major proportions.

Long-term use of cocaine may produce the following:




Inhaled: stuffy, runny nose; ulcerated or perforated septum


Smoked: damaged lungs; increased susceptibility to infection


Injected: HIV or other blood-related diseases; infections; embolism


Hallucinogens


Naturally occurring hallucinogens (psychedelics) are found in some species of mushrooms (psilocybin), in cactus (peyote), and in synthetic form (LSD [lysergic acid diethylamide]). Currently, young people are using MDMA (Ecstasy). Animal research has shown that MDMA can damage neurons that contain serotonin.

Hallucinogens are ingested orally and produce physical symptoms of tremors, heart palpitations, tachycardia, blurred vision, and diaphoresis. Psychologic symptoms include euphoria or dysphoria, (extreme perceptual disturbances). The person may experience perceived separation of self from the environment (depersonalization) or heightened sensual stimulation. Colors become brilliant; sounds, smells, and tastes are intense; and synesthesia (seeing sounds, hearing visions) may occur. Other symptoms include fear of going crazy, labile mood, experiencing two feelings at the same time, or an excessive sense of attachment toward or detachment from others.

Flashbacks and “bad trips” are often associated with the use of psychedelics. Flashbacks are a reexperiencing of the drug-induced state that occurs in the absence of recent ingestion of the drug—a reliving of the event. Bad trips refer to a frightening panic reaction to hallucinogen intake. Psychoactive substances may trigger latent psychotic disorders.


Inhalants


Inhalants are volatile substances such as hydrocarbons, esters, ketones, and glycols that are found in paints, glue, gasoline, cleaners, spray-can propellants, and typewriter correction fluids, among other substances. When breathed in through the mouth or nose, these substances act on the CNS, producing dizziness, ataxia, excitement, and euphoria that may lead to aggressiveness and impulsivity. Permanent kidney, liver, and brain damage can result, or death may occur because of depressed respiratory centers.



Opiates


Opiates are powerful pain relievers. Opium, the basic substance in this group, occurs naturally in the opium poppy. Several psychoactive substances are derived from opium, including morphine, heroin, and codeine. Many synthetic opiates are used in the United States, including propoxyphene (Darvon), meperidine (Demerol), and methadone (used in treatment programs to assist in withdrawal from natural opioids, especially heroin).

Opioids may be ingested, smoked, or nasally inhaled. Clinical effects include drowsiness, analgesia, decreased consciousness, mood changes, euphoria, and pleasurable feelings. Heroin, used medically in other countries because of its excellent analgesic properties, is illegal in the United States. Opiates are respiratory depressants and can lead to death through their direct effect on the respiratory centers of the brain. Deaths caused by heroin continue at an alarming rate in the United States because of increased use and unknown purity (potency) of the illegal drugs.

Heroin is the most commonly abused opiate; it is estimated that there are more than 600,000 heroin addicts in the United States alone. In countries where opiates originate (mainly the Middle and Far East), the incidence per capita is much higher. Once established, opiate dependence dominates the individual’s entire life and is very difficult to stop.

Narcotic analgesics (OxyContin, Vicodin, Percocet) continue to be abused in increasing numbers. Drug use normally begins with a physician’s prescription for pain relief and frequently evolves into abuse and dependence. As a result, clients may “doctor shop” to maintain the drug habit or seek the medications illegally.


Phencyclidine


Phencyclidine (PCP) and similarly acting arylcyclohexyl-amines such as ketamine or thienylcycloexylpiperidine (TCP) can be taken orally, taken intravenously, smoked, or inhaled. PCP and ketamine were originally used as general anesthetics but are now used only by veterinarians because of the severe symptoms that clients may experience when emerging from anesthesia.

Users of these drugs find the effects unpredictable, but many experience feelings of euphoria, warmth, floating sensations, and vivid fantasy in the form of hallucinations and oblivion. Users may also experience depersonalization, estrangement, and isolation. Psychosis can occur and may be more prevalent than currently recognized because of the unreliability of commonly used drug detection tests. Intoxication can lead to convulsions, coma, and death. Several deaths occur each year because of increased use of ketamine with other drugs during rave parties and other recreational settings.


Sedatives, Hypnotics, and Anxiolytics


A pattern of use relating to each substance in this category and leading to dependence usually begins through either (1) a prescription given by a physician that eventually fosters prominent drug-seeking behaviors in which the client may subsequently seek several physicians to obtain an adequate supply of the substance or (2) illegal sources obtained for the purposes of “getting high” with peers or for use with other illicit drugs to enhance, potentiate, or counteract effects. All sedatives, hypnotics, and anxiolytics are cross-tolerant with each other and with alcohol.

Benzodiazepines are among the most widely prescribed and abused legal drugs in the United States. Tolerance for remarkably high doses can occur, and, as is true for most other substances in this category, these drugs are capable of producing physical and psychologic dependence. Withdrawal from these substances by addicted individuals can cause death.



INTERVENTIONS



Treatment Settings


Multiple levels of intervention are considered when treating clients who abuse or who are dependent on substances. Clients may voluntarily appear for treatment because of their personal needs and decisions for life changes. A client may arrive for treatment as a result of family or employer ultimatums. Clients may also be admitted involuntarily to an acute care facility because of results of drug use; the client may be dangerous to self, aggressive or dangerous toward others, or unable to meet basic living needs because of drug abuse. Whether the arrival is voluntary or involuntary, a thorough assessment of the client is imperative.

Treatment is started based on client assessment and history of drug use, including how long the client has been using before admission and the type and amount of drug. The nurse in an acute care setting is prepared to intervene with the client’s physical needs and problems in addition to one or more psychiatric disorders. Clients who have been using large doses of drugs over an extended period usually have neglected their physical health and nutrition.


Levels of Treatment




The nurse interacts with the client using principles for substance disorders and comorbid psychiatric diagnoses. Clients who abuse drugs may suffer from withdrawal effects soon after admission, so nurses need good physical nursing skills, clear boundaries, and kind but firm limit-setting skills to contend with the client’s unique personality, physical/psychologic craving for the substance, and drug-seeking behaviors.

The second level of treatment focuses on chronic health problems, both physical and psychologic, that result from excessive or long-term use of drugs. This treatment includes necessary medical support, psychoeducation groups that assist the client toward insight, self-help groups such as Alcoholics Anonymous (AA), individual therapy, support therapy, and family therapy.

The third level focuses on assisting the client to rebuild a life without drugs. The nurse helps the client develop plans for substituting healthy behaviors for drug-taking activities; replacing drug-using acquaintances with those who support sober living; building relationships; expanding the social support network; ensuring housing; securing finances; setting appointments and keeping a calendar; resolving to stay associated with a healthy therapeutic environment; and continuing to take responsibility for conducting own life without drugs.


Hospitalization




Physical conditions other than an overdose that warrant medical attention include drug toxicity, withdrawal syndrome, infections, and physical debilities such as dehydration, malnutrition, and allergic reactions. Psychologic impairment for which clients may be hospitalized can manifest in one or more psychiatric syndromes (aggressive behaviors that cause danger to self or others, or behaviors causing grave disability of the client). Examples include suicidal or homicidal threats, gestures, and attempts and the inability of the client to meet personal needs because of compromised mental state.


Medications


Clients admitted to treatment facilities may receive medications to alleviate acute symptoms of withdrawal from psychoactive substances. Most frequently prescribed medications are anxiolytics for excessive anxiety, antihypertensives to control blood pressure, and anticonvulsants to prevent seizures. After discharge, Antabuse (disulfiram) is a deterrent drug that causes a violent toxic reaction when alcohol is also ingested. It works by inhibiting the enzyme that prevents accumulation of acetaldehyde in the blood. Clients become nauseated, hypotensive, flushed, hot, dizzy, and numb and experience malaise.


Drug Screening


Drug screening is useful when a client (with paranoia or schizophrenia) cannot present a reliable drug history. Blood levels are useful in determining the client’s degree of intoxication. With multiple drug use the presence of multiple drug levels will help to determine the order of detoxification.


Alcohol Withdrawal


Treatment for alcohol withdrawal includes benzodiazepines such as chlordiazepoxide (Librium) and oxazepam (Serax). Other treatments include clonidine (Catapres); an alpha 2-blocker, carbamazepine (Tegretol); and valproate (Depakote). Antipsychotics may be useful in major withdrawals.

General management includes multivitamins and thiamine (vitamin B 1) and folic acid. Injectable thiamine is usually given by large-volume intravenous (IV) solution, or a single-dose intramuscular (IM) injection, followed by daily oral vitamin B 1 tablet. This regimen is used to prevent Wernicke’s encephalopathy, a condition associated with alcoholism, and thiamine deficiency, characterized by confusion, disorientation, and amnesia.


Uncomplicated Withdrawal Schedule.


All hospital-ized patients should be monitored for vital signs. Minor signs of withdrawal include the following:




▪ Elevated systolic blood pressure (>160 mm Hg)


▪ Elevated diastolic blood pressure (>90 mm Hg)


▪ Pulse >90


▪ Temperature >38°C (100.4°F)


▪ Nausea, vomiting, diaphoresis, or tremor

A typical withdrawal regimen with chlordiazepoxide, if the client is able to take oral medications, consists of the following:




▪ Day 1: 50 mg every 4 hours


▪ Day 2: 50 mg every 6 hours


▪ Day 3: 25 mg every 4 hours


▪ Day 4: 25 mg every 6 hours


▪ Day 5: none

Chlordiazepoxide as needed (prn) is generally not recommended, and the client should not be awakened if a scheduled dose is due. Dosage should be adjusted upward if withdrawal symptoms occur, or the dose should be decreased if the client is overly sedated. Oxazepam or diazepam (Valium) can be used as an alternative to chlordiazepoxide. Barbiturates are not typically used because of the potentiation of CNS effects.


Complicated Withdrawal.


If the patient is to have nothing by mouth (NPO) or is vomiting, IM or IV diazepam (10 to 15 mg) or lorazepam (Ativan) (2 to4 mg) may be used as an equivalent dose to 50 mg of chlordiazepoxide. Resume oral chlordiazepoxide as soon as possible. Delirium tremens may occur. Rule out medical illness such as pneumonia and meningitis.

Diazepam (10 mg IV) may be given initially, followed by 5 mg IV until the client is stable. Alternatives to diazepam include lorazepam (2 to 4 mg). Benzodiazepines should be tapered over a period of up to 5 days. Prophylactic anticonvulsants such as phenytoin (Dilantin) may be used to prevent seizures if the client has a history of seizures. In general, anticonvulsants are not necessary. Naltrexone (ReVia) (initial dose 25 mg first day, then 50 mg daily thereafter) may be useful to reduce craving. Disulfiram (Antabuse) (250 mg) may be used as a deterrent for drinking when the client is motivated and reliable.


Opiate Withdrawal


Treatment for opiate withdrawal consists of the following:





































TABLE 9-3 Methadone Dosing Schedule for Opiate-Dependent Clients
N ote: Hospitals and treatment centers that are not specifically licensed for detoxification of opiate dependence with methadone must limit the use of methadone for detoxication to 72 hours (Code of Federal Regulations, 1983).
h, Hours; IM, intramuscular; q, every.
*Initial methadone dose is determined by the presenting signs and symptoms. This initial methadone dose is repeated in 12 hours. Supplementary doses of methadone (5 to 10 mg) are provided if withdrawal signs are either not suppressed or reappear during the first 24 hours. Once the initial 24-hour dose is established, the dose is tapered at a rate of 20% per day or every other day for a short-acting or long-acting opiate, respectively. Methadone is given on a q12h or q8h dosage schedule (q8–12h), with vital signs taken before each dose. It is unusual for a client to require more than 40 mg during the initial 24 hours of withdrawal. If the client is initially unable to tolerate oral medications, IM methadone (10 mg) should be given as soon as possible, followed with the initial oral dose of methadone, as calculated from the presenting grade of withdrawal.
Grade Signs and Symptoms Initial Methadone Dose* (mg)
1 Lacrimation, rhinorrhea, diaphoresis, yawning, restlessness, insomnia 5
2 Dilated pupils, piloerection, muscle twitching, myalgia, arthralgia, abdominal pain 10
3 Tachycardia, hypertension, tachypnea, fever, anorexia, nausea, extreme restlessness 15
4 Diarrhea, vomiting, dehydration, hyperglycemia, hypotension 20


▪ Clonidine (Both patches or tablets can be used. The patch is placed for up to 7 days.)


▪ Combination of naltrexone and clonidine


Acute Withdrawal Symptoms.


The following regimens are designed to manage the acute medical withdrawal symptoms of opiates such as heroin and morphine. Methadone is a synthetic opioid similar to morphine but tolerated orally.

Methadone and levomethadyl (hydrochloride) acetate (levo-alpha-acetylmethadol[LAMM]) maintenance are appropriate for clients with a long history (more than 1 year) of opiate abuse.

Naltrexone (ReVia), a nonaddictive substance, is an alternative pharmacologic treatment, and its effectiveness is limited by noncompliance and low treatment retention.

Naloxone (Narcan), a narcotic antagonist and synthetic cogener of oxymorphone, is indicated for the following:




▪ Complete or partial reversal of narcotic depression, including respiratory depression induced by opioids, as well as natural and synthetic narcotics


▪ Diagnosis of suspected or acute opioid overdose

There is no clinical experience with naloxone overdose in humans (DuPont Merck Pharmaceutical Company, 1990).


Anxiolytic/Hypnotic Withdrawal


A typical low-dose benzodiazepine withdrawal schedule is as follows:




▪ If the client is using long-acting benzodiazepines such as Librium, the current drug should be used and is tapered 20% per week. The tapering schedule is slowed toward the end if necessary.


▪ If the client is using short-acting benzodiazepines such as Serax, a long-acting benzodiazepine should be considered, and the tapering schedule described previously is used.


▪ Alprazolam (Xanax) is tapered slowly, and a dose reduction should not exceed 0.5 mg every 3 days.

High-dose withdrawal involves the following; tolerance testing is used before a withdrawal procedure is initiated:




▪ Diazepam is commonly used with tolerance testing, and if the tolerance test is positive, the client can be started with diazepam at 40% of the test dose, gradually tapering by 10% every week. Daily dosages should be divided.


▪ If the client is using long-acting benzodiazepines, begin with 40% of the current dose, and taper 10% every week.


▪ Dosages should be adjusted upward if withdrawal symptoms occur and should be reduced if the client is intoxicated.


Therapies



Individual Therapy


Problems often seen in clients with substance abuse and dependence include denial, low self-concept and self-esteem, anger, manipulation, and dependency needs. Interventions for these problems are located in care plans throughout the text. Denial is a major defense mechanism in drug abuse, and the client must admit and face the drug problem before recovery is possible. Another priority includes support of the client in his or her journey to wellness. This support is best provided within a trusting relationship.

The nurse provides a mature, nonjudgmental role model and firm, kind limit setting for manipulative behaviors. Realistic encouragement and support are also given as the client learns new ways to tolerate life’s inevitable anxieties without drugs and to expand his or her social support network to include healthy, sober significant others.



Confrontation Interventions


Constructive confrontation is often necessary to affect behavioral change. On that premise the family, boss, friends (all significantly involved individuals) meet with the client in this intervention. Each member, openly and honestly states how the client’s drug use has impacted his or her life, for example:




Child: Dad, you missed all my games in school because you were drunk.


You really hurt me when you didn’t make it to my graduation.


Wife: We haven’t had a romantic or intimate evening in 3 years because you are always intoxicated.


You think you’re a good lover, but you never think of me any more.


Boss: Your performance has deteriorated to the point that I’m going to have to let you go.

Then each person tells the client what must change (treatment plan) or suffer consequences.



Halfway Houses


Transitional living arrangements provide recovering substance abusers interim homes and programs between detoxification and the eventual permanent home. They allow a slow adjustment to the community and ease the client’s return home, which may have been a source of difficulty before becoming sober. Family therapy seems to be an essential component of successful recovery.


Employee Assistance Programs


Many employers have established employee assistance programs (EAPs) to help employees recover from drug or alcohol dependence while retaining their positions; some make participation mandatory if the individual desires continued employment. Statistics for loss of dollars from lost productivity related to substance dependence have risen dramatically in the past decade, and EAPs have proved profitable alternatives to firing trained and skilled personnel.


Family Therapy


Family therapy is a critical component in the ongoing recovery of the person who uses alcohol or drugs, as members attempt to eliminate enabling and codependent behaviors that perpetuate the problem. Therapy is directed toward helping the family gain awareness of the negative effects of enabling and codependent behaviors and developing strategies based on confrontational approaches and appropriate support (refer to Care Plan: Disabled Family Coping, p. 383). Support and encouragement of the client/family unit are emphasized.


PROGNOSIS AND DISCHARGE CRITERIA


Prognosis for substance-related disorders is guarded and depends on many factors, including:




▪ Length of time drugs were abused


▪ Type of drugs abused


▪ Familial history


▪ Unique biology


▪ Current stressors


▪ Past experience and success at managing own life responsibly


▪ Desire (and commitment) to be sober


▪ Degree of self-honesty


▪ Motivation for life change


▪ Support network


▪ Access to therapeutic contacts


▪ Involvement with self-help groups

Some clients with drug problems complete treatment the first time and remain sober, while other clients have to repeat treatment several times (recidivism). Some clients do not succeed in staying sober. Nurses remain hopeful and appropriately supportive but realistic when treating clients. Avoidance of enabling is crucial, in conjunction with encouragement and healthy support.

Discharge criteria are as follows:

Client:




▪ Maintains abstinence.


▪ Admits to lifelong dependence on psychoactive substances.


▪ Expresses knowledge of continual process of recovery (“one day at a time”).


▪ Verbalizes realistic goals.


▪ Maintains attendance in support group (AA, Narcotics Anonymous [NA]).


▪ Expresses increased self-esteem.


▪ Verbalizes decreased guilt, loneliness, shame, despair, and anger.


▪ Demonstrates methods and strategies for managing anxiety, frustration, and anger.


▪ Lists tangible substitutes to replace drug-seeking, drug-taking behaviors (hobbies, school, employment, volunteer work, social functions).


▪ States feeling in control of own life.


▪ Expresses hope for future.


▪ Attends self-help group (client and family).


▪ Abandons people and situations that influence and contribute to drug-taking behaviors.


▪ States consequences of psychoactive substances on biopsychosocial/cultural/spiritual well-being.


▪ States names and phone numbers of resources to contact when unable to cope or feeling a need to revert to substance-taking behaviors.


▪ Investigates substance abuse assistance programs such as EAPs.


▪ Continues with AA if warranted.


▪ Supports family and/or significant others to attend Al-Anon and Alateen.

The Client and Family Teaching box on the next page provides guidelines for client and family teaching in the management of substance-related disorders.

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Mar 17, 2017 | Posted by in NURSING | Comments Off on Substance-Related Disorders

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