RhoGAM is a concentrated solution of immune globulin containing Rh_o(D) antibodies.

I.M. RhoGAM injection keeps the Rh-negative mother from producing active antibody responses and forming anti-Rh_o(D) to Rh-positive fetal blood cells and endangering future Rh-positive neonates.

RhoGAM is indicated for the Rh-negative mother after abortion, ectopic pregnancy, or delivery of a neonate having Rh_o(D)-positive or D^u-positive blood and Coombs’-negative cord blood, accidental transfusion of Rh-positive blood, amniocentesis, abruptio placentae, or abdominal trauma.

It’s given to the mother within 72 hours after she gives birth to prevent future maternal sensitization.

It’s also given at about 28 weeks’ gestation to protect the fetus of the Rh-negative mother.