CHAPTER 21

Rheumatologic Disorders

CHAPTER OBJECTIVES

• Distinguish between unifactorial and multifactorial causes in rheumatic diseases.
  
• Identify the most common skeletal dysplasias.
  
• Identify cell lines that cause bone loss such as osteoporosis.
  
• Discuss gene penetrance and variable expressivity in osteoarthritis versus rheumatoid arthritis.
  
• Review the current surveillance, diagnosis, and treatment recommendations for systemic lupus erythematosus.

KEY TERMS

Achondrodysplasia

Apoptosis

Acetylsalicylic acid (ASA)

Concordance

Cytokines

DMARDs

Dysplasias

Eburnation

Enthesitis

Epitopes

Interleukins

MTX

Multifactorial

NSAIDs

Oligoarthritis

Osteopenia

Osteoporosis

Pannus

Rhizomelia

Senescence

Unifactorial

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1. Introduction
2. Osteogenesis Imperfecta
3. Marfan Syndrome
4. Ethical, Legal, and Social Issues

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