BP

Bisacodyl

Proprietary

Dulcolax^® (Boehringer Ingelheim Ltd)

Group

Stimulant laxative

Uses/indications

Constipation

Type of drug

GSL

Presentation

Smooth white torpedo-shaped suppositories (P)
Gastroresistant tablets (GSL)

Dosage

Tablet 5–10 mg nocte, action over 10–12 h
One 10 mg suppository

Route of admin

Oral, P.R.

Contraindications

In patients with ileus, intestinal obstruction, acute abdominal conditions including appendicitis, acute inflammatory bowel diseases, and severe abdominal pain associated with nausea and vomiting, which may be indicative of the aforementioned severe conditions
In severe dehydration and in patients with known hypersensitivity to bisacodyl or any other component of the product
Should not be used when anal fissures or ulcerative proctitis with mucosal damage are present
Avoid use in children under 10 years
Should not be used for more than 5 consecutive days without investigating the cause of constipation

Side effects

Abdominal cramps; not for prolonged use as it can cause atonic non-functioning colon and hypokalaemia

Pharmacodynamic properties

Stimulation of the mucosa of the large intestine results in colonic peristalsis with promotion of accumulation of water, and electrolytes, in the colonic lumen. This results in a stimulation of defaecation, reduction of transit time and softening of the stool. Stimulation of the rectum causes increased motility and a feeling of rectal fullness

Interactions

If used with antacids and milk products the resistance of the coating of the tablets may be reduced resulting in dyspepsia and gastric irritation

Fetal risk

No data available but use only if the benefits outweigh the risks

Breastfeeding

Considered safe but use only if the benefits outweigh the risks