Pregabalin(pray gab’ ah lin)
GD-Pregabalin (CAN), Lyrica, PMS-Pregabalin (CAN), ratio-Pregabalin (CAN)
PREGNANCY CATEGORY C
CONTROLLED SUBSTANCE C-V
Drug Classes
Analgesic
Antiepileptic
Calcium channel modulator
Therapeutic Actions
Binds to alpha2-delta sites on the nerves in the CNS, which reduces the calcium influx into the cell and decreases the release of neurotransmitters into the synaptic cleft, resulting in less stimulation of the nerve; in lab studies, it also increases the transport and density of GABA, which is known to suppress nerve activity.
Indications
Management of acute pain associated with diabetic peripheral neuropathy
Management of post-herpetic neuralgia
Adjunct therapy of adult patients with partial onset seizures
Management of fibromyalgia
Management of neuropathic pain due to spinal cord injuries
Unlabeled use: Treatment of generalized anxiety disorders
Contraindications and Cautions
Contraindicated with known hypersensitivity to pregabalin or any component of the drug, lactation.
Use cautiously with diabetes, HF, renal impairment, pregnancy.
Available Forms
Capsules—25, 50, 75, 100, 150, 200, 225, 300 mg; oral solution—20 mg/mL
Dosages
Adults
Neuropathic pain associated with diabetic neuropathy: Initially, 50 mg PO tid; within a week titrate to 100 mg PO tid. Maximum, 300 mg/day.
Postherpetic neuralgia: 75–150 mg PO bid or 50–100 mg PO tid as needed to control pain; may be adjusted up to a maximum dose of 600 mg/day.
Partial-onset seizures: Initially, 75 mg/day PO; titrate to 150–600 mg/day PO, divided into two to three doses.
Fibromyalgia: Initially, 75 mg PO bid. May be increased within 1 wk to 150 mg PO bid. Maximum dose, 450 mg/day.
Neuropathic pain associated with spinal cord injuries: Initially, 75 mg PO bid; increase to 150 mg PO bid within 1 wk. If relief is not sufficient within 2–3 wk, may increase to 300 mg PO bid.
Pediatric patients
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