Pregabalin



Pregabalin





(pray gab’ ah lin)

GD-Pregabalin (CAN), Lyrica, PMS-Pregabalin (CAN), ratio-Pregabalin (CAN)

PREGNANCY CATEGORY C

CONTROLLED SUBSTANCE C-V


Drug Classes

Analgesic

Antiepileptic

Calcium channel modulator


Therapeutic Actions

Binds to alpha2-delta sites on the nerves in the CNS, which reduces the calcium influx into the cell and decreases the release of neurotransmitters into the synaptic cleft, resulting in less stimulation of the nerve; in lab studies, it also increases the transport and density of GABA, which is known to suppress nerve activity.


Indications



  • Management of acute pain associated with diabetic peripheral neuropathy


  • Management of post-herpetic neuralgia


  • Adjunct therapy of adult patients with partial onset seizures


  • Management of fibromyalgia


  • Management of neuropathic pain due to spinal cord injuries


  • Unlabeled use: Treatment of generalized anxiety disorders



Available Forms

Capsules—25, 50, 75, 100, 150, 200, 225, 300 mg; oral solution—20 mg/mL


Dosages

Adults



  • Neuropathic pain associated with diabetic neuropathy: Initially, 50 mg PO tid; within a week titrate to 100 mg PO tid. Maximum, 300 mg/day.


  • Postherpetic neuralgia: 75–150 mg PO bid or 50–100 mg PO tid as needed to control pain; may be adjusted up to a maximum dose of 600 mg/day.


  • Partial-onset seizures: Initially, 75 mg/day PO; titrate to 150–600 mg/day PO, divided into two to three doses.


  • Fibromyalgia: Initially, 75 mg PO bid. May be increased within 1 wk to 150 mg PO bid. Maximum dose, 450 mg/day.


  • Neuropathic pain associated with spinal cord injuries: Initially, 75 mg PO bid; increase to 150 mg PO bid within 1 wk. If relief is not sufficient within 2–3 wk, may increase to 300 mg PO bid.

Pediatric patients

Only gold members can continue reading. Log In or Register to continue

Stay updated, free articles. Join our Telegram channel

Jul 21, 2016 | Posted by in NURSING | Comments Off on Pregabalin

Full access? Get Clinical Tree

Get Clinical Tree app for offline access