Phenelzine Sulfate

Phenelzine Sulfate
(fen’ el zeen)
Nardil
PREGNANCY CATEGORY C
Drug Classes
Antidepressant
MAOI
Therapeutic Actions
Irreversibly inhibits MAO, an enzyme that breaks down biogenic amines, such as epinephrine, norepinephrine, and serotonin, thus allowing these biogenic amines to accumulate in neuronal storage sites. According to the biogenic amine hypothesis, this accumulation of amines is responsible for the clinical efficacy of MAOIs as antidepressants.
Indications
  • Treatment of patients with depression characterized as atypical, nonendogenous, or neurotic; patients who are unresponsive to other antidepressive therapy; and patients in whom other antidepressive therapy is contraindicated
  • Unlabeled uses: Treatment of bulimia, PTSD, chronic migraine not responsive to standard treatment, social anxiety disorders, migraine prophylaxis
Available Forms
Tablets—15 mg
Dosages
Adults
Initially, 15 mg PO tid. Increase dosage to at least 60 mg/day at a rapid pace consistent with patient tolerance. Many patients require therapy at 60 mg/day for at least 4 wk before response. Some patients may require 90 mg/day. After maximum benefit is achieved, reduce dosage slowly over several weeks. Maintenance may be 15 mg/day or every other day.
Pediatric patients younger than 16 yr
Not recommended.
Geriatric patients
Elderly patients are more prone to develop adverse effects; adjust dosage accordingly.
Pharmacokinetics
Route Onset Peak Duration
Oral Slow 1 hr 48–96 hr
Metabolism: Hepatic; T1/2: 12 hr
Distribution: Crosses placenta; enters breast milk
Excretion: Urine
Jul 21, 2016 | Posted by in NURSING | Comments Off on Phenelzine Sulfate

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